(Q21120457)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P27169

Paraoxonase1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P27169

epithelial sodium channel

1 reference

Transporter Classification Database ID

1.A.6.2.6

hierarchical database ID heuristic

2 October 2019

based on heuristic

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

protein homodimerization activity

1 reference

8 April 2019

Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

1 reference

8 April 2019

aryldialkylphosphatase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

4 references

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

26 September 2017

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

26 September 2017

Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

arylesterase activity

Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities

6 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

26 September 2017

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

26 September 2017

Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

1 reference

8 April 2019

phospholipid binding

1 reference

8 April 2019

Human serum Paraoxonase/Arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids : apolipoprotein A-I stabilizes activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

aryldialkylphosphatase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

5 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

8 April 2019

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

8 April 2019

Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

IBA

arylesterase activity

Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

8 April 2019

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

8 April 2019

Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

acyl-L-homoserine-lactone lactonohydrolase activity

IBA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

1 reference

8 April 2019

cell component

blood microparticle

1 reference

26 September 2017

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

intracellular membrane-bounded organelle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

spherical high-density lipoprotein particle

1 reference

8 April 2019

Isolation and characterization of human apolipoprotein M-containing lipoproteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

high-density lipoprotein particle

Human serum Paraoxonase/Arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids : apolipoprotein A-I stabilizes activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

8 April 2019

8 April 2019

Paraoxonase 1 (PON1) enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells: a possible role for lysophosphatidylcholine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

extracellular exosome

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

4 references

8 April 2019

TAS

8 April 2019

The human plasma proteome: a nonredundant list developed by combination of four separate sources

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

8 April 2019

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

3 references

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

26 September 2017

Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

8 April 2019

Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

IBA

extracellular exosome

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

blood microparticle

1 reference

8 April 2019

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

biological process

response to fatty acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

positive regulation of transporter activity

1 reference

8 April 2019

Paraoxonase 1 (PON1) enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells: a possible role for lysophosphatidylcholine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

negative regulation of plasma lipoprotein oxidation

1 reference

8 April 2019

Purified human serum PON1 does not protect LDL against oxidation in the in vitro assays initiated with copper or AAPH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

lipid metabolism

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

carboxylic acid catabolic process

1 reference

8 April 2019

Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

cholesterol metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

positive regulation of binding

1 reference

8 April 2019

Paraoxonase 1 (PON1) enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells: a possible role for lysophosphatidylcholine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

response to nutrient levels

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

response to fluoride

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

positive regulation of cholesterol efflux

1 reference

8 April 2019

Paraoxonase 1 (PON1) enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells: a possible role for lysophosphatidylcholine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

response to external stimulus

NAS

1 reference

26 September 2017

Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27169&geneProductId=UniProtKB:P27169

organophosphate catabolic process

NAS

1 reference

8 April 2019

Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

aromatic compound catabolic process

1 reference

8 April 2019

Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

phosphatidylcholine metabolic process

1 reference

8 April 2019

Paraoxonase 1 (PON1) enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells: a possible role for lysophosphatidylcholine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

dephosphorylation

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

lipoxygenase pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27169

1 reference

8 April 2019

Transporter Classification Database ID

TAS

Identifiers

MeSH descriptor ID

C468406

subject named as

PON1 protein, human

0 references

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

9 August 2016

language of work or name

English

1.A.6.2.6

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023