(Q21122476)

English

Peroxisomal biogenesis factor 12

mammalian protein found in Homo sapiens

PAF-3
Peroxin-12
PEX12
peroxin 12
peroxisome assembly factor 3
peroxisome assembly protein 12

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Statements

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

13 November 2019

ubiquitin-protein transferase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

6 references

8 April 2019

PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

8 April 2019

PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

8 April 2019

Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

8 April 2019

PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

8 April 2019

PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

8 April 2019

Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

determination method

IEA

cell component

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

determination method

IEA

peroxisomal importomer complex

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

determination method

IEA

integral component of peroxisomal membrane

4 references

26 September 2017

PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00623&geneProductId=UniProtKB:O00623

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00623&geneProductId=UniProtKB:O00623

26 September 2017

PEX12 encodes an integral membrane protein of peroxisomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00623&geneProductId=UniProtKB:O00623

26 September 2017

Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00623&geneProductId=UniProtKB:O00623

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00623&geneProductId=UniProtKB:O00623

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00623&geneProductId=UniProtKB:O00623

26 September 2017

PEX14 is required for microtubule-based peroxisome motility in human cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00623&geneProductId=UniProtKB:O00623

3 references

integral component of peroxisomal membrane

5 references

8 April 2019

PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

8 April 2019

Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

8 April 2019

PEX12 encodes an integral membrane protein of peroxisomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

determination method

IBA

biological process

peroxisome organization

1 reference

8 April 2019

A novel PEX12 mutation identified as the cause of a peroxisomal biogenesis disorder with mild clinical phenotype, mild biochemical abnormalities in fibroblasts and a mosaic catalase immunofluorescence pattern, even at 40 degrees C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

determination method

IMP

protein import into peroxisome matrix

3 references

26 September 2017

PEX5 binds the PTS1 independently of Hsp70 and the peroxin PEX12

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00623&geneProductId=UniProtKB:O00623

26 September 2017

Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00623&geneProductId=UniProtKB:O00623

26 September 2017

PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import

http://www.ebi.ac.uk/QuickGO/annotations?protein=O00623&geneProductId=UniProtKB:O00623

determination method

IMP

protein monoubiquitination

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

determination method

IBA

protein ubiquitination

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

determination method

TAS

protein targeting to peroxisome

protein import into peroxisome matrix

4 references

8 April 2019

PEX5 binds the PTS1 independently of Hsp70 and the peroxin PEX12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

8 April 2019

Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

8 April 2019

PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00623

1 reference

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/O00623

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

Transporter Classification Database ID

3.A.20.1.1

2 references

stated in

Transporter Classification database

retrieved

13 March 2020

stated in

Transporter Classification database

retrieved

29 April 2020

(Q21122476)

Peroxisomal biogenesis factor 12

Statements

Identifiers

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