(Q21122491)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28328

Peroxisomal Protein Importer

1 reference

Transporter Classification Database ID

3.A.20.1.1

retrieved

2 October 2019

hierarchical database ID heuristic

Zinc finger, RING-type, protein family

1 reference

Zinc finger, C3HC4 RING-type, protein family

1 reference

Pex, N-terminal domain, protein family

1 reference

Zinc finger, RING-type, conserved site, protein family

1 reference

Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p

1 reference

13 November 2019

1 reference

13 November 2019

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

8 April 2019

Two different targeting signals direct human peroxisomal membrane protein 22 to peroxisomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

8 April 2019

The peroxisomal receptor Pex19p forms a helical mPTS recognition domain

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

ubiquitin protein ligase activity

IPI

4 references

26 September 2017

Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p recycling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28328&geneProductId=UniProtKB:P28328

26 September 2017

Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28328&geneProductId=UniProtKB:P28328

26 September 2017

Properties of the ubiquitin-pex5p thiol ester conjugate.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28328&geneProductId=UniProtKB:P28328

26 September 2017

PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28328&geneProductId=UniProtKB:P28328

1 reference

8 April 2019

The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

integral component of peroxisomal membrane

IDA

1 reference

8 April 2019

The peroxisomal membrane targeting elements of human peroxin 2 (PEX2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28328&geneProductId=UniProtKB:P28328

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28328&geneProductId=UniProtKB:P28328

26 September 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28328&geneProductId=UniProtKB:P28328

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28328&geneProductId=UniProtKB:P28328

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28328&geneProductId=UniProtKB:P28328

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28328&geneProductId=UniProtKB:P28328

26 September 2017

PEX14 is required for microtubule-based peroxisome motility in human cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28328&geneProductId=UniProtKB:P28328

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

8 April 2019

PEX14 is required for microtubule-based peroxisome motility in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

negative regulation of fibroblast proliferation

1 reference

8 April 2019

The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

protein import into peroxisome matrix

1 reference

8 April 2019

Defective PEX gene products correlate with the protein import, biochemical abnormalities, and phenotypic heterogeneity in peroxisome biogenesis disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

fatty acid beta-oxidation

The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene

protein destabilization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

very long-chain fatty acid metabolic process

1 reference

8 April 2019

Restoration of PEX2 peroxisome assembly defects by overexpression of PMP70

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

A human gene responsible for Zellweger syndrome that affects peroxisome assembly

peroxisome organization

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

8 April 2019

Restoration of PEX2 peroxisome assembly defects by overexpression of PMP70

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

negative regulation of epithelial cell proliferation

IEA

1 reference

8 April 2019

The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

protein ubiquitination

1 reference

8 April 2019

protein targeting to peroxisome

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28328

Transporter Classification Database ID

TAS

Identifiers

MeSH descriptor ID

D000074428

subject named as

Peroxisomal Biogenesis Factor 2

0 references

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

3.A.20.1.1

2 references

Transporter Classification database

retrieved

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata