(Q21123247)

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

HD/PDEase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

phosphoric diester hydrolase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

3',5'-cyclic-GMP phosphodiesterase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

1 reference

8 April 2019

Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

cGMP-inhibited cyclic-nucleotide phosphodiesterase activity

IPI

1 reference

8 April 2019

Expression and mutagenesis of the catalytic domain of cGMP-inhibited phosphodiesterase (PDE3) cloned from human platelets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

3',5'-cyclic-AMP phosphodiesterase activity

TAS

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

integral component of membrane

IBA

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

2 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

regulation of meiotic nuclear division

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

1 reference

8 April 2019

Molecular cloning and chromosomal assignment of the human homologue of the rat cGMP-inhibited phosphodiesterase 1 (PDE3A)--a gene involved in fat metabolism located at 11p 15.1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

TAS

cGMP-mediated signaling

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

cAMP-mediated signaling

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

cellular response to transforming growth factor beta stimulus

IMP

1 reference

8 April 2019

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

positive regulation of vascular permeability

IEP

1 reference

8 April 2019

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

positive regulation of oocyte development

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

diterpenoid metabolic process

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

negative regulation of vascular permeability

1 reference

8 April 2019

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

cellular response to cGMP

IMP

1 reference

8 April 2019

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans

IDA

cAMP catabolic process

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

5 June 2018

Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14432&geneProductId=UniProtKB:Q14432

G protein-coupled receptor signaling pathway

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

negative regulation of cAMP-mediated signaling

TAS

3 references

8 April 2019

Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14432

physically interacts with

IBA

1 reference

7114

17 August 2016

1 reference

5167

17 August 2016

1 reference

7148

English

guanosine cyclic 3',5'-phosphate

17 August 2016

has use

enzyme inhibitor

1 reference

2347

17 August 2016

1 reference

7399

17 August 2016

1 reference

7202

17 August 2016

1 reference

5225

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1752

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2051955

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL799

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL19449

has part(s)

3'5'-cyclic nucleotide phosphodiesterase, conserved site

1 reference

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

1 reference

HD/PDEase domain

1 reference