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(Q21124634)
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Lymphotoxin alpha
mammalian protein found in Homo sapiens
tumor necrosis factor beta
tumor necrosis factor ligand superfamily member 1
LT-alpha
tumor necrosis factor ligand 1E
truncated lymphotoxin alpha
LTA
TNF-beta
lymphotoxin-alpha
TNF superfamily, member 1
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P01374
part of
Tumour necrosis factor-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P01374
lymphotoxin-alpha
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P01374
Tumour necrosis factor domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Tumour necrosis factor, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P01374
encoded by
LTA
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P01374
molecular function
cytokine activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P01374
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
tumor necrosis factor receptor binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
signaling receptor binding
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Characterization of receptors for human tumour necrosis factor and their regulation by gamma-interferon
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
TAS
protein binding
determination method
IPI
1 reference
retrieved
5 June 2018
stated in
Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01374&geneProductId=UniProtKB:P01374
determination method
IPI
cell component
membrane
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P01374
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
plasma membrane
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
TAS
extracellular region
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P01374
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
extracellular space
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P01374
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
biological process
positive regulation of chronic inflammatory response to antigenic stimulus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
response to hypoxia
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
response to nutrient
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
cell-cell signaling
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
TAS
positive regulation of humoral immune response mediated by circulating immunoglobulin
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
positive regulation of interferon-gamma production
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
tumor necrosis factor-mediated signaling pathway
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
TAS
response to lipopolysaccharide
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
humoral immune response
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
immune response
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
positive regulation of apoptotic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
lymph node development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
positive regulation of glial cell proliferation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
negative regulation of fibroblast proliferation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
signal transduction
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
TAS
defense response to Gram-positive bacterium
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
apoptotic process
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
TAS
regulation of signaling receptor activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01374
determination method
IEA
has part(s)
Tumour necrosis factor, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P01374
Tumour necrosis factor domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P01374
Identifiers
RefSeq protein ID
NP_000586
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4049
NP_001153212
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4049
XP_011512917
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4049
XP_011512918
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4049
XP_011512919
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4049
XP_011512920
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
4049
UniProt protein ID
P01374
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
P01374
Ensembl protein ID
ENSP00000395976
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000395976
ENSP00000402413
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000402413
ENSP00000403495
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000403495
ENSP00000412555
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000412555
ENSP00000413450
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000413450
ENSP00000416509
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000416509
ENSP00000395895
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000395895
ENSP00000387924
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000387924
ENSP00000416337
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000416337
ENSP00000372793
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000372793
ENSP00000372791
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000372791
ENSP00000407133
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000407133
ENSP00000372991
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000372991
ENSP00000383131
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000383131
PDB structure ID
1TNR
1 reference
stated in
UniProt
UniProt protein ID
P01374
retrieved
4 August 2016
language of work or name
English
4MXV
1 reference
stated in
UniProt
UniProt protein ID
P01374
retrieved
4 August 2016
language of work or name
English
4MXW
1 reference
stated in
UniProt
UniProt protein ID
P01374
retrieved
4 August 2016
language of work or name
English
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