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(Q21127088)
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Ring finger protein 125
mammalian protein found in Homo sapiens
T-cell RING activation protein 1
ring finger protein 125, E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase RNF125
RNF125
RING finger protein 125
T-cell ring protein identified in activation screen
TRAC-1
In more languages
default values for all languages
No label defined
No description defined
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q96EQ8
part of
Zinc finger, RING/FYVE/PHD-type
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q96EQ8
membrane protein
1 reference
based on heuristic
inferred from GOA cell component → membrane
Zinc finger, RING-type, protein family
1 reference
based on heuristic
inferred from protein domain or family
Drought induced 19 protein type, zinc-binding domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Zinc finger C2HC RNF-type, protein family
1 reference
based on heuristic
inferred from protein domain or family
Zinc finger, RING-type, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q96EQ8
encoded by
RNF125
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q96EQ8
molecular function
metal ion binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IEA
p53 binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
RNF125 is a ubiquitin-protein ligase that promotes p53 degradation
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IPI
protein binding
determination method
IPI
4 references
retrieved
8 April 2019
stated in
A non-canonical role of the p97 complex in RIG-I antiviral signaling
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IPI
retrieved
8 April 2019
stated in
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IPI
retrieved
8 April 2019
stated in
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IPI
transferase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IEA
zinc ion binding
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IDA
ubiquitin conjugating enzyme binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IPI
ubiquitin protein ligase activity
determination method
IDA
3 references
retrieved
8 April 2019
stated in
RNF125 is a ubiquitin-protein ligase that promotes p53 degradation
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IDA
retrieved
8 April 2019
stated in
A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IDA
retrieved
8 April 2019
stated in
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IDA
cell component
intracellular membrane-bounded organelle
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IDA
membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IEA
Golgi membrane
determination method
IEA
IDA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IEA
retrieved
8 April 2019
stated in
T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IDA
Golgi apparatus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IEA
VCP-NPL4-UFD1 AAA ATPase complex
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
A non-canonical role of the p97 complex in RIG-I antiviral signaling
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IDA
biological process
adaptive immune response
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IEA
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
determination method
IBA
1 reference
retrieved
27 February 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96EQ8&geneProductId=UniProtKB:Q96EQ8
determination method
IBA
protein ubiquitination
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IEA
immune system process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IEA
ubiquitin-dependent protein catabolic process
determination method
IDA
2 references
retrieved
8 April 2019
stated in
A non-canonical role of the p97 complex in RIG-I antiviral signaling
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IDA
retrieved
8 April 2019
stated in
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IDA
negative regulation of type I interferon production
determination method
IDA
2 references
retrieved
8 April 2019
stated in
A non-canonical role of the p97 complex in RIG-I antiviral signaling
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IDA
retrieved
8 April 2019
stated in
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IDA
negative regulation of RIG-I signaling pathway
determination method
IDA
2 references
retrieved
8 April 2019
stated in
A non-canonical role of the p97 complex in RIG-I antiviral signaling
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IDA
retrieved
8 April 2019
stated in
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IDA
protein polyubiquitination
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125
GOA
curator
UniProt
UniProt protein ID
Q96EQ8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96EQ8
determination method
IDA
has part(s)
Zinc finger, RING-type, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q96EQ8
Drought induced 19 protein type, zinc-binding domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q96EQ8
Zinc finger, RING-type
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q96EQ8
Zinc finger C2HC RNF-type
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q96EQ8
Identifiers
RefSeq protein ID
NP_060301
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
54941
XP_011524347
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
54941
XP_011524348
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
54941
XP_011524349
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
54941
UniProt protein ID
Q96EQ8
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q96EQ8
Ensembl protein ID
ENSP00000217740
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000217740
ENSP00000463935
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000463935
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(0 entries)
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Multilingual sites
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