Wikidata

(Q21130874)

English

Cell division cycle 27

mammalian protein found in Homo sapiens

  • APC3
  • cell division cycle 27 homolog
  • H-NUC
  • CDC27Hs
  • anaphase promoting complex subunit 3
  • anaphase-promoting complex, protein 3
  • CDC27 homolog
  • nuc2 homolog
  • D0S1430E, D17S978E
  • Anaphase-promoting complex subunit 3
  • CDC27
  • cell division cycle protein 27 homolog
In more languages
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
23 references
retrieved
8 April 2019
stated in
Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
GOA
curator
UniProt
UniProt protein ID
P30260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex
GOA
curator
UniProt
UniProt protein ID
P30260
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
Systematic analysis of human protein complexes identifies chromosome segregation proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
Atomic structure of the APC/C and its mechanism of protein ubiquitination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
PP2A delays APC/C-dependent degradation of separase-associated but not free securin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
retrieved
8 April 2019
stated in
C/EBP{delta} targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30260
determination method or standard
IPI
cell component
biological process

Identifiers

RefSeq protein ID
 
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