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3-hydroxy-3-methylglutaryl coenzyme A reductase
human protein (annotated by UniProtKB/TrEMBL A0A024RAP2)
In more languages
edit
Statements
instance of
protein
0 references
part of
Hydroxymethylglutaryl-CoA reductase, metazoan
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A0A024RAP2
Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A0A024RAP2
Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A0A024RAP2
Hydroxymethylglutaryl-CoA reductase, N-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A0A024RAP2
Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A0A024RAP2
Sterol-sensing domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
UniProt protein ID
A0A024RAP2
retrieved
17 September 2016
encoded by
HMGCR
1 reference
stated in
UniProt
UniProt protein ID
A0A024RAP2
retrieved
21 March 2016
language of work or name
English
molecular function
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
protein homodimerization activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
hydroxymethylglutaryl-CoA reductase (NADPH) activity
determination method
IEA
3 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
A0A024RAP2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
NADP binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
oxidoreductase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
A0A024RAP2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
protein phosphatase 2A binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
cell component
integral component of membrane
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
A0A024RAP2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
endoplasmic reticulum membrane
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
A0A024RAP2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
intracellular membrane-bounded organelle
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
A0A024RAP2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
endoplasmic reticulum
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
A0A024RAP2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
biological process
visual learning
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
negative regulation of striated muscle cell apoptotic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
response to nutrient
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
coenzyme A metabolic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
positive regulation of skeletal muscle tissue development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
positive regulation of cardiac muscle cell apoptotic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
negative regulation of insulin secretion involved in cellular response to glucose stimulus
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
human ageing
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
negative regulation of apoptotic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
isoprenoid biosynthetic process
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
negative regulation of MAP kinase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
positive regulation of cell population proliferation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
positive regulation of ERK1 and ERK2 cascade
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
negative regulation of wound healing
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
cholesterol biosynthetic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
ubiquinone metabolic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
myoblast differentiation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
response to ethanol
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
positive regulation of stress-activated MAPK cascade
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
positive regulation of smooth muscle cell proliferation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
negative regulation of protein catabolic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
negative regulation of protein secretion
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
negative regulation of amyloid-beta clearance
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:A0A024RAP2
determination method
IEA
has part(s)
Sterol-sensing domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A0A024RAP2
Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/A0A024RAP2
Identifiers
RefSeq protein ID
NP_000850.1
1 reference
stated in
UniProt
UniProt protein ID
A0A024RAP2
retrieved
21 March 2016
language of work or name
English
XP_011541660.1
1 reference
stated in
UniProt
UniProt protein ID
A0A024RAP2
retrieved
21 March 2016
language of work or name
English
UniProt protein ID
A0A024RAP2
1 reference
stated in
UniProt
UniProt protein ID
A0A024RAP2
retrieved
21 March 2016
language of work or name
English
Sitelinks
Wikipedia
(0 entries)
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Wikibooks
(0 entries)
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Wikinews
(0 entries)
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Wikiquote
(0 entries)
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Wikisource
(0 entries)
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Wikiversity
(0 entries)
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Wikivoyage
(0 entries)
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Wiktionary
(0 entries)
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Multilingual sites
(0 entries)
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