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Phospholipase D2
mammalian protein found in Homo sapiens
phospholipase D2
phosphatidylcholine-hydrolyzing phospholipase D2
PLD2
choline phosphatase 2
PLD1C
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O14939
part of
PX domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O14939
PH-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O14939
Phospholipase D, eukaryotic type
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O14939
membrane proteins
1 reference
based on heuristic
inferred from GOA cell component → membrane
pleckstrin homology domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Phox homologous domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Phospholipase D/Transphosphatidylase family
1 reference
based on heuristic
inferred from protein domain or family
Phospholipase D-like domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O14939
encoded by
PLD2
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O14939
molecular function
phospholipase D activity
determination method
IEA
TAS
3 references
retrieved
8 April 2019
stated in
Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O14939
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IEA
N-acylphosphatidylethanolamine-specific phospholipase D activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O14939
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IEA
protein binding
determination method
IPI
4 references
retrieved
8 April 2019
stated in
Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IPI
retrieved
8 April 2019
stated in
The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IPI
retrieved
8 April 2019
stated in
The elucidation of novel SH2 binding sites on PLD2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IPI
retrieved
8 April 2019
stated in
Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IPI
catalytic activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IEA
phosphatidylinositol binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IEA
hydrolase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O14939
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IEA
cell component
Golgi apparatus
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IBA
endoplasmic reticulum membrane
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
TAS
membrane
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O14939
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IEA
plasma membrane
determination method
TAS
2 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
TAS
retrieved
8 April 2019
stated in
Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
TAS
presynapse
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IEA
biological process
Fc-gamma receptor signaling pathway involved in phagocytosis
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
TAS
lipid metabolism
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O14939
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IEA
cell motility
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IBA
small GTPase mediated signal transduction
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
TAS
lipid catabolic process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O14939
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IEA
synaptic vesicle recycling
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
The role of oxidative stress in Parkinson's disease
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
TAS
cytoskeleton organization
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
TAS
phosphatidic acid biosynthetic process
determination method
IEA
TAS
2 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IEA
inositol lipid-mediated signaling
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14939
determination method
IEA
physically interacts with
oleic acid
1 reference
stated in
IUPHAR/BPS Guide to PHARMACOLOGY
Guide to Pharmacology Ligand ID
1054
language of work or name
English
retrieved
17 August 2016
has part(s)
Phospholipase D/Transphosphatidylase
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O14939
Phospholipase D-like domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O14939
pleckstrin homology domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O14939
Phox homologous domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O14939
Identifiers
RefSeq protein ID
NP_001230037
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
5338
NP_002654
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
5338
XP_005256753
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
5338
XP_016880253
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
5338
UniProt protein ID
O14939
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
O14939
Ensembl protein ID
ENSP00000263088
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000263088
ENSP00000459571
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000459571
ENSP00000458795
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000458795
ENSP00000459304
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000459304
ENSP00000460250
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000460250
ENSP00000460477
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000460477
ENSP00000461459
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000461459
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Wikiquote
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Wikisource
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Multilingual sites
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