(Q21443395)

English

Twinkle mtDNA helicase

mammalian protein found in Homo sapiens

T7-like mitochondrial DNA helicase
TWNK
mitochondrial twinkle protein
T7 helicase-related protein with intramitochondrial nucleoid localization
ataxin 8
twinkle protein, mitochondrial
T7 gp4-like protein with intramitochondrial nucleoid localization
progressive external ophthalmoplegia 1 protein
ATXN8

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Statements

1 reference

13 November 2019

1 reference

1 December 2016

P-loop containing nucleoside triphosphate hydrolase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q96RR1

Archaeal primase DnaG/twinkle, TOPRIM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA helicase, DnaB-like, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

DNA and RNA binding by the mitochondrial lon protease is regulated by nucleotide and protein substrate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method

IEA

single-stranded DNA binding

1 reference

8 April 2019

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method

IDA

5'-3' DNA helicase activity

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method

TAS

mitochondrial nucleoid

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

8 April 2019

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

8 April 2019

The layered structure of human mitochondrial DNA nucleoids

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method

IDA

biological process

mitochondrial transcription

1 reference

8 April 2019

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method

IMP

mitochondrion organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method

TAS

protein homooligomerization

1 reference

8 April 2019

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method

IDA

mitochondrial DNA replication

3 references

8 April 2019

TWINKLE Has 5' -> 3' DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

8 April 2019

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

8 April 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method

IEA

protein hexamerization

1 reference

8 April 2019

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method

IDA

cellular response to glucose stimulus

1 reference

8 April 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method

IEA

DNA unwinding involved in DNA replication

1 reference

8 April 2019

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96RR1

determination method

IEA

has part(s)

DNA helicase, DnaB-like, C-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q96RR1

Archaeal primase DnaG/twinkle, TOPRIM domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q96RR1

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

0 references

Sitelinks

Wikipedia(2 entries)

cawiki Twinkle
enwiki Twinkle (protein)

(Q21443395)

Twinkle mtDNA helicase

Statements

Identifiers

Sitelinks

Wikipedia(2 entries)

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

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