(Q21495727)

English

Folliculin

mammalian protein found in Mus musculus

folliculin
Flcn
birt-Hogg-Dube syndrome protein homolog

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8QZS3

Folliculin/SMCR8, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Folliculin, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Folliculin/SMCR8, tripartite DENN domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

guanyl-nucleotide exchange factor activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

protein binding

determination method

1 reference

9 May 2019

Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

protein-containing complex binding

determination method

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

determination method

1 reference

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8QZS3&geneProductId=UniProtKB:Q8QZS3

determination method

plasma membrane

determination method

determination method

cell-cell contact zone

determination method

biological process

regulation of pro-B cell differentiation

determination method

1 reference

9 May 2019

The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of protein kinase B signaling

determination method

1 reference

9 May 2019

Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

positive regulation of protein phosphorylation

determination method

1 reference

9 May 2019

Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

regulation of TOR signaling

determination method

1 reference

9 May 2019

Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of mitochondrion organization

determination method

1 reference

14 February 2019

Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

in utero embryonic development

determination method

1 reference

9 May 2019

Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of mitochondrial DNA metabolic process

determination method

1 reference

9 May 2019

Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of gene expression

determination method

1 reference

9 May 2019

Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of TOR signaling

determination method

3 references

9 May 2019

Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of cellular respiration

determination method

1 reference

9 May 2019

Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

regulation of histone acetylation

determination method

1 reference

9 May 2019

Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

cell-cell junction assembly

determination method

1 reference

9 May 2019

Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of ATP biosynthetic process

determination method

1 reference

9 May 2019

Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of ERK1 and ERK2 cascade

determination method

negative regulation of angiogenesis

determination method

1 reference

9 May 2019

Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of cell proliferation involved in kidney development

determination method

4 references

9 May 2019

Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of muscle tissue development

determination method

1 reference

9 May 2019

Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of post-translational protein modification

determination method

1 reference

9 May 2019

Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

positive regulation of intrinsic apoptotic signaling pathway

determination method

1 reference

9 May 2019

Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

positive regulation of TOR signaling

determination method

1 reference

9 May 2019

The role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

positive regulation of autophagy

determination method

1 reference

27 March 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8QZS3&geneProductId=UniProtKB:Q8QZS3

determination method

determination method

1 reference

9 May 2019

Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

energy homeostasis

determination method

1 reference

9 May 2019

Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of transcription by RNA polymerase II

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

regulation of protein phosphorylation

determination method

mitochondrion organization

determination method

1 reference

14 February 2019

Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of cell growth

determination method

negative regulation of cell migration

determination method

positive regulation of transforming growth factor beta receptor signaling pathway

determination method

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

determination method

regulation of cytokinesis

determination method

negative regulation of Rho protein signal transduction

determination method

TORC1 signaling

determination method

1 reference

14 February 2019

Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

TORC2 signaling

determination method

1 reference

14 February 2019

Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

positive regulation of cell adhesion

determination method

positive regulation of transcription by RNA polymerase II

determination method

negative regulation of cold-induced thermogenesis

determination method

1 reference

9 May 2019

Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

negative regulation of protein localization to nucleus

determination method

negative regulation of mitochondrion organization

determination method

negative regulation of TORC2 signaling

determination method

1 reference

9 May 2019

Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8QZS3

determination method

Folliculin, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8QZS3

Folliculin/SMCR8, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8QZS3

Folliculin/SMCR8, tripartite DENN domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8QZS3

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000091696

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000091696

ENSMUSP00000099758

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000099758

ENSMUSP00000037675

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000037675

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21495727&oldid=2023132082"