(Q21497911)

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox protein SIX1, N-terminal SD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

sequence-specific DNA binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Identification and expression of six family genes in mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

DNA-binding transcription activator activity, RNA polymerase II-specific

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

transcription cis-regulatory region binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

5 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

27 March 2018

Localization of Six4/AREC3 in the developing mouse retina; implications in mammalian retinal development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

27 March 2018

Identification and expression of six family genes in mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

27 March 2018

Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

27 March 2018

Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Localization of Six4/AREC3 in the developing mouse retina; implications in mammalian retinal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Identification and expression of six family genes in mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

transcription regulator complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

negative regulation of neuron apoptotic process

biological process

1 reference

14 February 2019

Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

embryonic skeletal system morphogenesis

1 reference

14 February 2019

Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

1 reference

14 February 2019

Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

positive regulation of branching involved in ureteric bud morphogenesis

1 reference

14 February 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development

male gonad development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

olfactory placode formation

1 reference

14 February 2019

Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

1 reference

14 February 2019

Development of gustatory papillae in the absence of Six1 and Six4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

anatomical structure development

1 reference

27 March 2018

Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

1 reference

14 February 2019

Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

trigeminal ganglion development

1 reference

14 February 2019

Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

negative regulation of apoptotic process

1 reference

14 February 2019

Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development

male sex determination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

skeletal muscle fiber differentiation

1 reference

14 February 2019

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

regulation of branch elongation involved in ureteric bud branching

1 reference

14 February 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

transcription, DNA-templated

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

fungiform papilla morphogenesis

1 reference

14 February 2019

Development of gustatory papillae in the absence of Six1 and Six4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis

generation of neurons

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

regulation of protein localization

1 reference

14 February 2019

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

positive regulation of transcription, DNA-templated

6 references

14 February 2019

Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo

inner ear morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development

male sex differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

positive regulation of ureteric bud formation

1 reference

14 February 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

regulation of synaptic assembly at neuromuscular junction

1 reference

14 February 2019

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

regulation of gene expression

1 reference

14 February 2019

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

protein localization to nucleus

1 reference

14 February 2019

Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

embryonic cranial skeleton morphogenesis

1 reference

14 February 2019

Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

negative regulation of satellite cell differentiation

1 reference

14 February 2019

Six family genes control the proliferation and differentiation of muscle satellite cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

regulation of epithelial cell proliferation

1 reference

14 February 2019

Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

negative regulation of transcription, DNA-templated

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

sarcomere organization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

metanephric mesenchyme development

1 reference

14 February 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

positive regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

pharyngeal system development

1 reference

14 February 2019

Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

transcription by RNA polymerase II

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61321&geneProductId=UniProtKB:Q61321

negative regulation of transcription, DNA-templated

3 references

14 February 2019

Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Six family genes control the proliferation and differentiation of muscle satellite cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61321

1 reference

Homeobox, conserved site

1 reference

stated in

Homeobox protein SIX1, N-terminal SD domain

1 reference

stated in