(Q21499115)

HAD-like superfamily

1 reference

P-type ATPase subfamily IIC, subunit alpha

1 reference

P-type ATPase, transmembrane domain superfamily

1 reference

P-type ATPase, cytoplasmic domain N

1 reference

HAD superfamily

1 reference

Cation-transporting P-type ATPase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cation-transporting P-type ATPase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

2 references

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

1 reference

14 February 2019

Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

P-type sodium:potassium-exchanging transporter activity

7 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDN2&geneProductId=UniProtKB:Q8VDN2

24 April 2018

The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDN2&geneProductId=UniProtKB:Q8VDN2

24 April 2018

Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDN2&geneProductId=UniProtKB:Q8VDN2

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDN2&geneProductId=UniProtKB:Q8VDN2

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDN2&geneProductId=UniProtKB:Q8VDN2

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDN2&geneProductId=UniProtKB:Q8VDN2

24 April 2018

Green fluorescence protein driven by the Na,K-ATPase α4 isoform promoter is expressed only in male germ cells of mouse testis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDN2&geneProductId=UniProtKB:Q8VDN2

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

3 references

14 February 2019

The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

1 reference

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDN2&geneProductId=UniProtKB:Q8VDN2

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

P-type sodium:potassium-exchanging transporter activity

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

Green fluorescence protein driven by the Na,K-ATPase α4 isoform promoter is expressed only in male germ cells of mouse testis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

P-type potassium transmembrane transporter activity

IBA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

integral component of membrane

cell component

3 references

1 reference

11 October 2018

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8VDN2&geneProductId=UniProtKB:Q8VDN2

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

Differential involvement of Na(+),K(+)-ATPase isozymes in preimplantation development of the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene)

IDA

apical plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

1 reference

14 February 2019

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

Na,K-ATPase from mice lacking the gamma subunit (FXYD2) exhibits altered Na+ affinity and decreased thermal stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

1 reference

14 February 2019

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

regulation of the force of heart contraction

HDA

biological process

negative regulation of heart contraction

1 reference

14 February 2019

The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation

response to glycoside

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

regulation of blood pressure

1 reference

14 February 2019

The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

positive regulation of heart contraction

IGI

1 reference

14 February 2019

Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

positive regulation of striated muscle contraction

1 reference

14 February 2019

The alpha(1)- and alpha(2)-isoforms of Na-K-ATPase play different roles in skeletal muscle contractility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

negative regulation of glucocorticoid biosynthetic process

1 reference

14 February 2019

Deficiency in Na,K-ATPase alpha isoform genes alters spatial learning, motor activity, and anxiety in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

establishment or maintenance of transmembrane electrochemical gradient

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

regulation of sodium ion transport

3 references

potassium ion transport

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDN2

3 references

cellular sodium ion homeostasis

3 references

cellular potassium ion homeostasis

3 references

sodium ion export across plasma membrane

3 references

potassium ion import across plasma membrane

3 references

P-type ATPase, phosphorylation site

1 reference

Cation-transporting P-type ATPase, C-terminal

1 reference

Cation-transporting P-type ATPase, N-terminal

1 reference