(Q21563543)

English

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase

scientific article

High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21179498%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21179498%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

circadian rhythm

0 references

Casein kinase 1, epsilon

1 reference

GOA release 2020-03-11

Period circadian clock 1

1 reference

GOA release 2020-03-11

Period circadian clock 2

1 reference

GOA release 2020-03-11

Tsuyoshi Hirota

1

object named as

Tsuyoshi Hirota

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Tsuyoshi

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Hirota

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18 January 2020

3

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Warren G Lewis

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Warren G

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Lewis

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18 January 2020

4

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Eric E Zhang

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Eric E

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Zhang

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18 January 2020

Ghislain Breton

5

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Ghislain Breton

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Ghislain

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Breton

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18 January 2020

Peter G. Schultz

11

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Peter G Schultz

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Peter G

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Schultz

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18 January 2020

author name string

Jae Wook Lee

2

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Jae Wook

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Lee

1 reference

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18 January 2020

Xianzhong Liu

6

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Xianzhong

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Liu

1 reference

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18 January 2020

Michael Garcia

7

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Garcia

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18 January 2020

Eric C Peters

8

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Eric C

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Peters

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18 January 2020

Jean-Pierre Etchegaray

9

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Jean-Pierre

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Etchegaray

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18 January 2020

David Traver

10

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David

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Traver

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18 January 2020

Steve A Kay

12

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Kay

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18 January 2020

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14 December 2010

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18 January 2020

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18 January 2020

8

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18 January 2020

e1000559

1 reference

Europe PubMed Central

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18 January 2020

12

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18 January 2020

copyright license

Creative Commons Attribution 4.0 International

14 December 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

A genome-wide RNAi screen for modifiers of the circadian clock in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Casein kinase 1 delta regulates the pace of the mammalian circadian clock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Network features of the mammalian circadian clock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Modeling of a human circadian mutation yields insights into clock regulation by PER2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Light-dependent development of circadian gene expression in transgenic zebrafish

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Coordination of circadian timing in mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

CK2alpha phosphorylates BMAL1 to regulate the mammalian clock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Posttranslational mechanisms regulate the mammalian circadian clock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Interactions between Casein kinase Iepsilon (CKIepsilon) and two substrates from disparate signaling pathways reveal mechanisms for substrate-kinase specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

A quantitative analysis of kinase inhibitor selectivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

The casein kinase 1 family: participation in multiple cellular processes in eukaryotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Essential role for ERK2 mitogen-activated protein kinase in placental development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Mammalian MAP kinase signalling cascades

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Cloning and characterization of rat casein kinase 1epsilon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

19 March 2017

The genetics of mammalian circadian order and disorder: implications for physiology and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

7 April 2017

The meter of metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

7 April 2017

A small molecule-kinase interaction map for clinical kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

7 April 2017

A clockwork web: circadian timing in brain and periphery, in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

7 April 2017

Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

Target profiling of small molecules by chemical proteomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

Quantitative proteomics reveals a dynamic interactome and phase-specific phosphorylation in the Neurospora circadian clock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

Metabolism control by the circadian clock and vice versa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

Mitogen-activated protein kinase is a functional component of the autonomous circadian system in the suprachiasmatic nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

Mammalian circadian signaling networks and therapeutic targets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

Intercellular coupling confers robustness against mutations in the SCN circadian clock network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

An opposite role for tau in circadian rhythms revealed by mathematical modeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

Mechanisms of drug inhibition of signalling molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

Finding new clock components: past and future.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

The mammalian circadian timing system: from gene expression to physiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

MAP kinases in the mammalian circadian system--key regulators of clock function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

A role for chemistry in stem cell biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

A combinatorial scaffold approach toward kinase-directed heterocycle libraries

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

12 September 2017

A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

27 September 2017

Circadian gene expression in cultured cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

27 September 2017

Serine phosphorylation of mCRY1 and mCRY2 by mitogen-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

27 September 2017

A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

27 September 2017

Beta-TrCP1-mediated degradation of PERIOD2 is essential for circadian dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

30 May 2018

A role for glycogen synthase kinase-3beta in the mammalian circadian clock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

30 May 2018

Real-time reporting of circadian-regulated gene expression by luciferase imaging in plants and mammalian cells.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000559

21 January 2018

Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3 beta.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000559

21 January 2018

Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1000559

21 January 2018

The CK1 gene family: expression patterning in zebrafish development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3001897

29 November 2018

Characterization and expression patterns of the MAPK family in zebrafish

1 reference

https://pubmed.ncbi.nlm.nih.gov/21179498

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Automated video image analysis of larval zebrafish locomotor rhythms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21179498

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PBIO.1000559

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21179498%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21179498%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21179498%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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