(Q21979829)

Cytoplasmic protein NCK

1 reference

SH2 domain superfamily

1 reference

SH2 domain, protein family

1 reference

Nck1, SH3 domain 2, protein family

1 reference

Nck1, SH3 domain 3, protein family

1 reference

Nck1, SH3 domain 1, protein family

1 reference

Nck1, SH2 domain, protein family

1 reference

SH3 domain, protein family

1 reference

protein domain specific binding

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

Identification of a ten-amino acid proline-rich SH3 binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

Regulation of process retraction and cell migration by EphA3 is mediated by the adaptor protein Nck1

IPI

ephrin receptor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

protein kinase inhibitor activity

IPI

eukaryotic initiation factor eIF2 binding

4 references

9 May 2019

Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

9 May 2019

c-Abl phosphorylates Dok1 to promote filopodia during cell spreading

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

9 May 2019

The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

9 May 2019

Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

molecular adaptor activity

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

1 reference

9 May 2019

The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

1 reference

9 May 2019

Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

IDA

endoplasmic reticulum

1 reference

9 May 2019

regulation of cell migration

biological process

1 reference

9 May 2019

Regulation of process retraction and cell migration by EphA3 is mediated by the adaptor protein Nck1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

positive regulation of actin filament polymerization

IGI

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

9 May 2019

Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

actin filament organization

1 reference

9 May 2019

The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

positive regulation of translation in response to endoplasmic reticulum stress

3 references

ephrin receptor signaling pathway

1 reference

9 May 2019

Regulation of process retraction and cell migration by EphA3 is mediated by the adaptor protein Nck1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

substrate-dependent cell migration, cell extension

1 reference

9 May 2019

Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

negative regulation of cell death

IGI

response to other organism

1 reference

9 May 2019

Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

positive regulation of neuron projection development

1 reference

9 May 2019

Regulation of process retraction and cell migration by EphA3 is mediated by the adaptor protein Nck1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

9 May 2019

Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

9 May 2019

Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

1 reference

9 May 2019

The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

negative regulation of PERK-mediated unfolded protein response

3 references

negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

9 May 2019

Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

regulation of translation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network

lamellipodium assembly

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

positive regulation of transcription by RNA polymerase II

negative regulation of protein kinase activity

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99M51

1 reference

SH3 domain

1 reference

Nck1, SH3 domain 2

1 reference

Nck1, SH3 domain 1

1 reference

Nck1, SH3 domain 3

1 reference

Nck1, SH2 domain

1 reference