(Q21981240)

English

Cadherin 2

mammalian protein found in Mus musculus

Cdh2
cadherin-2
neural cadherin
N-cadherin

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Catenin binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15116

Cadherin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15116

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15116

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

Cadherin, cytoplasmic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cadherin prodomain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cadherin-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cadherin conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

metal ion binding

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

calcium ion binding

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

protein binding

determination method

11 references

UniProt protein ID

9 August 2016

language of work or name

14 February 2019

Expression and function of connexin 43 protein in mouse and human retinal pigment epithelial cells as hemichannels and gap junction proteins.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPρ/PTPRT)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

mARVCF cellular localisation and binding to cadherins is influenced by the cellular context but not by alternative splicing

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

gamma-catenin binding

determination method

3 references

alpha-catenin binding

determination method

3 references

calcium ion binding

determination method

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Structure-function analysis of cell adhesion by neural (N-) cadherin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

cytoskeletal protein binding

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

identical protein binding

determination method

3 references

14 February 2019

Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Two-step adhesive binding by classical cadherins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

protein homodimerization activity

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

protein-containing complex binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

cadherin binding

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

nitric-oxide synthase binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

adherens junction

determination method

6 references

UniProt protein ID

9 August 2016

language of work or name

14 February 2019

NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

integral component of membrane

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

plasma membrane raft

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

14 February 2019

Flotillin microdomains stabilize cadherins at cell-cell junctions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

determination method

4 references

UniProt protein ID

9 August 2016

language of work or name

14 February 2019

Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

cell-cell junction

determination method

5 references

UniProt protein ID

9 August 2016

language of work or name

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Sex differences in expression and subcellular localization of heart rhythm determinant proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

POPX2 phosphatase regulates the KIF3 kinesin motor complex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

plasma membrane

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

cortical actin cytoskeleton

determination method

3 references

catenin complex

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

extracellular exosome

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

fascia adherens

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

intercalated disc

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

determination method

3 references

plasma membrane

determination method

6 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

integral component of plasma membrane

determination method

1 reference

14 February 2019

Structure-function analysis of cell adhesion by neural (N-) cadherin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

determination method

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

intercalated disc

determination method

6 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

The kinase domains of obscurin interact with intercellular adhesion proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

catenin complex

determination method

3 references

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

determination method

3 references

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

protein-containing complex

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

neuron projection

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

apical part of cell

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Role of β-Catenin in Synaptic Vesicle Localization and Presynaptic Assembly

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

glutamatergic synapse

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

biological process

regulation of signal transduction

determination method

2 references

UniProt protein ID

9 August 2016

language of work or name

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

cell-cell adhesion mediated by cadherin

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

blood vessel morphogenesis

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

determination method

5 references

UniProt protein ID

9 August 2016

language of work or name

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Beating is necessary for transdifferentiation of skeletal muscle‐derived cells into cardiomyocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

homophilic cell adhesion via plasma membrane adhesion molecules

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

determination method

1 reference

UniProt protein ID

9 August 2016

language of work or name

cell morphogenesis

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

cell-cell junction assembly

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

homophilic cell adhesion via plasma membrane adhesion molecules

determination method

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

N-Acetylglucosaminyltransferase V Expression Levels Regulate Cadherin-associated Homotypic Cell-Cell Adhesion and Intracellular Signaling Pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

N-Acetylglucosaminyltransferase V Expression Levels Regulate Cadherin-associated Homotypic Cell-Cell Adhesion and Intracellular Signaling Pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

regulation of myelination

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

regulation of protein localization

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

adherens junction organization

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

regulation of Rho protein signal transduction

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

modulation of chemical synaptic transmission

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

protein heterooligomerization

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

protein localization to plasma membrane

determination method

1 reference

14 February 2019

Flotillin microdomains stabilize cadherins at cell-cell junctions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

cell-cell adhesion

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Structure-function analysis of cell adhesion by neural (N-) cadherin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000025166

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000025166

ENSMUSP00000111516

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000111516

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21981240&oldid=2023203143"