Wikidata

(Q21981491)

English

Activating transcription factor 4

mammalian protein found in Mus musculus

  • cyclic AMP-dependent transcription factor ATF-4
  • c/EBP-related ATF
  • cAMP-dependent transcription factor ATF-4
  • tax-responsive enhancer element-binding protein 67 homolog
  • cyclic AMP-responsive element-binding protein 2
  • C/ATF
  • Atf4
  • cAMP-responsive element-binding protein 2
  • taxREB67 homolog
In more languages

Statements

molecular function
protein binding
determination method
IPI
13 references
retrieved
14 February 2019
stated in
FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice
GOA
curator
UniProt
UniProt protein ID
Q06507
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IPI
retrieved
14 February 2019
stated in
cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein
GOA
curator
UniProt
UniProt protein ID
Q06507
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IPI
retrieved
14 February 2019
stated in
Mouse NIPK interacts with ATF4 and affects its transcriptional activity
GOA
curator
UniProt
UniProt protein ID
Q06507
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IPI
retrieved
14 February 2019
stated in
Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IPI
retrieved
14 February 2019
stated in
DISC1, PDE4B, and NDE1 at the centrosome and synapse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IPI
retrieved
14 February 2019
stated in
ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IPI
retrieved
14 February 2019
stated in
SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IPI
retrieved
14 February 2019
stated in
Mouse NIPK interacts with ATF4 and affects its transcriptional activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IPI
retrieved
14 February 2019
stated in
The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IPI
retrieved
14 February 2019
stated in
ZIP kinase, a novel serine/threonine kinase which mediates apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IPI
retrieved
14 February 2019
stated in
ZIP kinase triggers apoptosis from nuclear PML oncogenic domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IPI
retrieved
14 February 2019
stated in
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IPI
retrieved
14 February 2019
stated in
Mouse NIPK interacts with ATF4 and affects its transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IPI
cell component
cytoplasm
determination method
IDA
IEA
ISO
7 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q06507
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IEA
retrieved
14 February 2019
stated in
FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes
GOA
curator
UniProt
UniProt protein ID
Q06507
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IDA
retrieved
14 February 2019
stated in
The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IDA
retrieved
14 February 2019
stated in
ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IDA
nucleus
determination method
IDA
IEA
ISO
8 references
retrieved
5 June 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507
determination method
ISO
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q06507
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507
determination method
IEA
retrieved
5 June 2018
stated in
FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes
GOA
curator
UniProt
UniProt protein ID
Q06507
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507
determination method
IDA
retrieved
5 June 2018
stated in
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507
determination method
IDA
retrieved
5 June 2018
stated in
ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507
determination method
IDA
retrieved
5 June 2018
stated in
The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06507&geneProductId=UniProtKB:Q06507
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
ISO
9 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q06507
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IEA
retrieved
14 February 2019
stated in
FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes
GOA
curator
UniProt
UniProt protein ID
Q06507
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IDA
retrieved
14 February 2019
stated in
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IDA
retrieved
14 February 2019
stated in
The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IDA
retrieved
14 February 2019
stated in
ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IBA
biological process
positive regulation of transcription by RNA polymerase II
determination method
IDA
IGI
IEA
IMP
ISO
9 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
ISO
retrieved
14 February 2019
stated in
The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IMP
retrieved
14 February 2019
stated in
SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IGI
retrieved
14 February 2019
stated in
Leptin regulation of bone resorption by the sympathetic nervous system and CART
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IGI
retrieved
14 February 2019
stated in
Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IGI
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IEA
retrieved
14 February 2019
stated in
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4
GOA
curator
UniProt
UniProt protein ID
Q06507
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IDA
retrieved
14 February 2019
stated in
Mouse NIPK interacts with ATF4 and affects its transcriptional activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IDA
retrieved
14 February 2019
stated in
Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IDA
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
determination method
IBA
IEA
IMP
ISO
5 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
ISO
retrieved
14 February 2019
stated in
Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IMP
retrieved
14 February 2019
stated in
Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06507
determination method
IBA

Identifiers

 
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