(Q21984529)

Immunoglobulin-like fold

1 reference

Immunoglobulin-like domain superfamily

1 reference

interleukin-12 beta

1 reference

membrane proteins

1 reference

inferred from GOA cell component → membrane

Fibronectin type III, protein family

1 reference

Interleukin-12 beta, central domain, protein family

1 reference

Immunoglobulin subtype 2, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Long hematopoietin receptor, soluble alpha chain, conserved site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

protein homodimerization activity

1 reference

9 May 2019

Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

cytokine receptor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

interleukin-12 alpha subunit binding

cytokine receptor binding

1 reference

9 May 2019

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

1 reference

9 May 2019

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

1 reference

9 May 2019

Localization of pro-inflammatory (IL-12, IL-15) and anti-inflammatory (IL-11, IL-13) cytokines at the foetomaternal interface during murine pregnancy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

interleukin-12 complex

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

interleukin-23 complex

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

endoplasmic reticulum lumen

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

1 reference

9 May 2019

Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

13 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Negative regulation of Toll-like-receptor signaling by IRF-4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

positive regulation of T cell mediated cytotoxicity

biological process

1 reference

9 May 2019

IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

natural killer cell activation

positive regulation of interferon-gamma production

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Accessory protein-like is essential for IL-18-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

response to organic substance

1 reference

9 May 2019

Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

cell surface receptor signaling pathway

1 reference

9 May 2019

Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

negative regulation of inflammatory response to antigenic stimulus

1 reference

9 May 2019

Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

positive regulation of T-helper 1 type immune response

IMP

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

positive regulation of T cell proliferation

defense response to virus

1 reference

9 May 2019

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

cellular response to interferon-gamma

1 reference

9 May 2019

Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

T-helper cell differentiation

cellular response to lipopolysaccharide

positive regulation of activated T cell proliferation

positive regulation of defense response to virus by host

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

defense response to protozoan

3 references

9 May 2019

Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

9 May 2019

Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

regulation of signaling receptor activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

T-helper 1 cell cytokine production

1 reference

9 May 2019

Accessory protein-like is essential for IL-18-mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

cytokine-mediated signaling pathway

IGI

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432

Long hematopoietin receptor, soluble alpha chain, conserved site

has part(s)

1 reference

Interleukin-12 beta, central domain

1 reference

fibronectin type III

1 reference

immunoglobulin subtype 2

1 reference

immunoglobulin-like domain

1 reference