(Q21984934)

Ureohydrolase domain superfamily

1 reference

Histone deacetylase, subgroup

1 reference

inferred from protein domain or family

histone deacetylases

1 reference

based on heuristic

1 reference

25 May 2022

1 reference

25 May 2022

DNA-binding transcription factor activity

1 reference

14 February 2019

Opposing LSD1 complexes function in developmental gene activation and repression programmes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

histone deacetylase activity (H4-K16 specific)

1 reference

9 May 2019

Histone deacetylase 2 (HDAC2) regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

NAD-dependent histone deacetylase activity (H3-K14 specific)

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

19 references

9 May 2019

CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Repression of Six3 by a corepressor regulates rhodopsin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Murine Sall1 represses transcription by recruiting a histone deacetylase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

The Mad1-Sin3B interaction involves a novel helical fold

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Chromatin regulation by Brg1 underlies heart muscle development and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

HDAC2 negatively regulates memory formation and synaptic plasticity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Repression of Six3 by a corepressor regulates rhodopsin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

sequence-specific DNA binding

IPI

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

histone deacetylase activity

5 references

5 June 2018

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70288&geneProductId=UniProtKB:P70288

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70288&geneProductId=UniProtKB:P70288

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70288&geneProductId=UniProtKB:P70288

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70288&geneProductId=UniProtKB:P70288

5 June 2018

S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70288&geneProductId=UniProtKB:P70288

Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation

chromatin DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

histone deacetylase binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

RNA polymerase II cis-regulatory region sequence-specific DNA binding

heat shock protein binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

promoter-specific chromatin binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

histone deacetylase activity

6 references

9 May 2019

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

transcription repressor complex

1 reference

9 May 2019

Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

RNA polymerase II transcription repressor complex

IPI

1 reference

9 May 2019

An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

1 reference

9 May 2019

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

2 references

histone deacetylase complex

1 reference

5 June 2018

Class II histone deacetylases: versatile regulators

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70288&geneProductId=UniProtKB:P70288

transcription regulator complex

TAS

1 reference

9 May 2019

Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

protein-containing complex

TAS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

odontogenesis of dentin-containing tooth

1 reference

9 May 2019

Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

positive regulation of proteolysis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

negative regulation of canonical Wnt signaling pathway

1 reference

9 May 2019

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

regulation of transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70288&geneProductId=UniProtKB:P70288

negative regulation of intrinsic apoptotic signaling pathway

1 reference

9 May 2019

Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

cardiac muscle cell development

1 reference

9 May 2019

Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

embryonic digit morphogenesis

1 reference

9 May 2019

Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

negative regulation of DNA-binding transcription factor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70288&geneProductId=UniProtKB:P70288

cellular response to trichostatin A

1 reference

9 May 2019

The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation

histone H4 deacetylation

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70288&geneProductId=UniProtKB:P70288

fungiform papilla formation

1 reference

9 May 2019

Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

regulation of protein kinase B signaling

1 reference

9 May 2019

Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

negative regulation of cardiac muscle cell proliferation

1 reference

9 May 2019

Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

hair follicle placode formation

1 reference

9 May 2019

Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

epidermal cell differentiation

1 reference

9 May 2019

Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

1 reference

9 May 2019

S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

regulation of protein deacetylation

1 reference

9 May 2019

Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

positive regulation of DNA-binding transcription factor activity

1 reference

9 May 2019

Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

negative regulation of apoptotic process

1 reference

9 May 2019

Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

negative regulation of transcription by RNA polymerase II

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

eyelid development in camera-type eye

1 reference

9 May 2019

Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

circadian regulation of gene expression

1 reference

9 May 2019

Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

protein deacetylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

histone H3-K27 methylation

1 reference

9 May 2019

The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development

neuron differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

regulation of sarcomere organization

1 reference

9 May 2019

Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development

hippocampus development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

positive regulation of transcription by RNA polymerase II

histone deacetylation

3 references

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70288&geneProductId=UniProtKB:P70288

positive regulation of epithelial to mesenchymal transition

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

positive regulation of interleukin-1 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

positive regulation of tumor necrosis factor production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

negative regulation of DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

negative regulation of dendritic spine development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

cellular response to hydrogen peroxide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

negative regulation of peptidyl-lysine acetylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

histone H3 deacetylation

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

positive regulation of male mating behavior

IBA

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70288

Histone deacetylase domain

has part(s)

1 reference