Wikidata

(Q21986189)

English

NLR family, CARD domain containing 4

mammalian protein found in Mus musculus

  • ice protease-activating factor
  • NLR family CARD domain-containing protein 4
  • Nlrc4
  • Ipaf
  • caspase recruitment domain family, member 12
  • caspase recruitment domain-containing protein 12
In more languages

Statements

molecular function
identical protein binding
determination method
IBA
IEA
IPI
ISO
6 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
ISO
retrieved
14 February 2019
stated in
Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IPI
retrieved
14 February 2019
stated in
Structural and biochemical basis for induced self-propagation of NLRC4.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IPI
retrieved
14 February 2019
stated in
Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IPI
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IBA
cell component
biological process
pyroptosis
determination method
IMP
5 references
retrieved
24 April 2018
stated in
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
Phosphorylation of NLRC4 is critical for inflammasome activation
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
defense response to bacterium
determination method
ISS
IEA
IMP
ISO
8 references
retrieved
24 April 2018
stated in
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
ISS
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
ISO
retrieved
24 April 2018
stated in
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
Phosphorylation of NLRC4 is critical for inflammasome activation
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IEA
inflammatory response
determination method
IEA
IMP
7 references
retrieved
24 April 2018
stated in
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
Phosphorylation of NLRC4 is critical for inflammasome activation
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3UP24&geneProductId=UniProtKB:Q3UP24
determination method
IEA
inflammatory response
determination method
IBA
IEA
IMP
8 references
retrieved
14 February 2019
stated in
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
Phosphorylation of NLRC4 is critical for inflammasome activation
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IBA
defense response to bacterium
determination method
IBA
IEA
IMP
ISO
ISS
9 references
retrieved
14 February 2019
stated in
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
ISS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
ISO
retrieved
14 February 2019
stated in
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
Phosphorylation of NLRC4 is critical for inflammasome activation
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IBA
pyroptosis
determination method
IBA
IMP
6 references
retrieved
14 February 2019
stated in
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
Phosphorylation of NLRC4 is critical for inflammasome activation
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
GOA
curator
UniProt
UniProt protein ID
Q3UP24
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IMP
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3UP24
determination method
IBA

Identifiers

 
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