(Q21987763)

English

Neurofibromin 1

mammalian protein found in Mus musculus

neurofibromin
neurofibromatosis-related protein NF-1
Nf1
neurofibromatosis 1

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

GTPase activator activity

determination method

7 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

phosphatidylcholine binding

determination method

protein binding

determination method

1 reference

8 April 2019

Neurofibromin binds to caveolin-1 and regulates ras, FAK, and Akt

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

microtubule binding

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

phosphatidylethanolamine binding

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

syndecan binding

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

intrinsic component of the cytoplasmic side of the plasma membrane

determination method

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04690&geneProductId=UniProtKB:Q04690

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

postsynaptic density

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

protein-containing complex

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

neuron projection

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

biological process

cellular response to heat

determination method

1 reference

8 April 2019

Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

regulation of angiogenesis

determination method

negative regulation of Ras protein signal transduction

determination method

7 references

8 April 2019

Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of cell-matrix adhesion

determination method

1 reference

8 April 2019

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

cell communication

determination method

1 reference

8 April 2019

Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

determination method

1 reference

8 April 2019

Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

positive regulation of neuron apoptotic process

determination method

3 references

8 April 2019

Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of oligodendrocyte differentiation

determination method

1 reference

8 April 2019

Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

observational learning

determination method

1 reference

8 April 2019

Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

smooth muscle tissue development

determination method

1 reference

8 April 2019

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

phosphatidylinositol 3-kinase signaling

determination method

1 reference

8 April 2019

Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

Ras protein signal transduction

determination method

7 references

8 April 2019

The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Nf1 has an essential role in endothelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

metanephros development

determination method

1 reference

8 April 2019

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of cell population proliferation

determination method

18 references

8 April 2019

Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Mouse models of tumor development in neurofibromatosis type 1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Mouse tumor model for neurofibromatosis type 1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of astrocyte differentiation

determination method

3 references

8 April 2019

Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Region-specific astrogliosis in brains of mice heterozygous for mutations in the neurofibromatosis type 1 (Nf1) tumor suppressor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

regulation of MAPK cascade

determination method

1 reference

8 April 2019

Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

collagen fibril organization

determination method

1 reference

8 April 2019

The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

glutamate secretion, neurotransmission

determination method

1 reference

8 April 2019

Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

myelination in peripheral nervous system

determination method

1 reference

8 April 2019

Neurofibromin, the neurofibromatosis type 1 Ras-GAP, is required for appropriate P0 expression and myelination

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of neuroblast proliferation

determination method

1 reference

8 April 2019

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

forebrain morphogenesis

determination method

1 reference

8 April 2019

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

heart development

determination method

5 references

8 April 2019

The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Neurofibromin deficiency in mice causes exencephaly and is a modifier for Splotch neural tube defects

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Nf1 has an essential role in endothelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

positive regulation of GTPase activity

determination method

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

amygdala development

determination method

1 reference

8 April 2019

Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of Rac protein signal transduction

determination method

1 reference

8 April 2019

Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of MAP kinase activity

determination method

4 references

8 April 2019

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Glycogen stored in skeletal but not in cardiac muscle in acid alpha-glucosidase mutant (Pompe) mice is highly resistant to transgene-encoded human enzyme

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

neural tube development

determination method

1 reference

8 April 2019

Neurofibromin deficiency in mice causes exencephaly and is a modifier for Splotch neural tube defects

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

artery morphogenesis

determination method

1 reference

8 April 2019

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

spinal cord development

determination method

1 reference

8 April 2019

The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of fibroblast proliferation

determination method

1 reference

8 April 2019

An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

positive regulation of adenylate cyclase activity

determination method

1 reference

8 April 2019

Neurofibromin regulates G protein-stimulated adenylyl cyclase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

peripheral nervous system development

determination method

1 reference

8 April 2019

Neurofibromin deficiency in mice causes exencephaly and is a modifier for Splotch neural tube defects

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

regulation of glial cell differentiation

determination method

1 reference

8 April 2019

Aberrant growth and differentiation of oligodendrocyte progenitors in neurofibromatosis type 1 mutants

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of protein kinase activity

determination method

Schwann cell development

determination method

1 reference

8 April 2019

Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

extracellular matrix organization

determination method

1 reference

8 April 2019

Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

determination method

1 reference

8 April 2019

The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

regulation of cell-matrix adhesion

determination method

1 reference

8 April 2019

Neurofibromin binds to caveolin-1 and regulates ras, FAK, and Akt

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of cell migration

determination method

6 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

osteoblast differentiation

determination method

1 reference

8 April 2019

Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of MAPK cascade

determination method

3 references

cerebral cortex development

determination method

1 reference

8 April 2019

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

regulation of gene expression

determination method

1 reference

8 April 2019

Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

determination method

3 references

8 April 2019

Induction of melanogenic abnormalities in NF1+/- mutant mice by DMBA

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

The neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL/6 mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

visual learning

determination method

5 references

8 April 2019

Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

A mouse model for the learning and memory deficits associated with neurofibromatosis type I

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

determination method

1 reference

14 February 2019

Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of neurotransmitter secretion

determination method

response to hypoxia

determination method

1 reference

8 April 2019

Nf1 haploinsufficiency augments angiogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

positive regulation of endothelial cell proliferation

determination method

1 reference

8 April 2019

Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

sympathetic nervous system development

determination method

gamma-aminobutyric acid secretion, neurotransmission

determination method

1 reference

8 April 2019

Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of osteoclast differentiation

determination method

1 reference

8 April 2019

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

adrenal gland development

determination method

1 reference

8 April 2019

The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

determination method

1 reference

8 April 2019

Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of endothelial cell proliferation

determination method

brain development

determination method

1 reference

8 April 2019

Neurofibromin deficiency in mice causes exencephaly and is a modifier for Splotch neural tube defects

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

forebrain astrocyte development

determination method

1 reference

8 April 2019

Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

regulation of cell population proliferation

determination method

1 reference

8 April 2019

Nf1 and Gmcsf interact in myeloid leukemogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

regulation of long-term synaptic potentiation

determination method

1 reference

8 April 2019

Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

positive regulation of apoptotic process

determination method

3 references

8 April 2019

Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

8 April 2019

Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of angiogenesis

determination method

1 reference

8 April 2019

Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

liver development

determination method

1 reference

8 April 2019

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

regulation of bone resorption

determination method

1 reference

8 April 2019

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

skeletal muscle tissue development

determination method

1 reference

8 April 2019

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

regulation of synaptic transmission, GABAergic

determination method

1 reference

8 April 2019

Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

extrinsic apoptotic signaling pathway via death domain receptors

determination method

1 reference

14 February 2019

Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

camera-type eye morphogenesis

determination method

1 reference

8 April 2019

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

hair follicle maturation

determination method

1 reference

8 April 2019

Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

positive regulation of neuron projection development

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

negative regulation of protein import into nucleus

determination method

1 reference

8 April 2019

Nf1 has an essential role in endothelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

regulation of neuron differentiation

determination method

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000071289

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000071289

ENSMUSP00000103886

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000103886

ENSMUSP00000120982

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000120982

ENSMUSP00000151975

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000151975

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