(Q21988430)

English

Phosphoinositide-3-kinase regulatory subunit 5

mammalian protein found in Mus musculus

p87 PI3K adapter protein
p84 PI3K adapter protein
phosphoinositide 3-kinase gamma adapter protein of 87 kDa
phosphoinositide-3-kinase, regulatory subunit 6
p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein
p84 PIKAP
Pik3r6
p87PIKAP
phosphoinositide 3-kinase regulatory subunit 6

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Statements

1 reference

25 May 2022

Phosphoinositide 3-kinase regulatory subunit 5/6

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q3U6Q4

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

25 May 2022

1 reference

25 May 2022

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

1 reference

14 February 2019

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

3 references

14 February 2019

PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

14 February 2019

p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

14 February 2019

Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

determination method

IPI

1-phosphatidylinositol-3-kinase regulator activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

14 February 2019

p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

determination method

IEA

phosphatidylinositol 3-kinase complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

determination method

IBA

biological process

positive regulation of T cell differentiation

1 reference

14 February 2019

Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio

GOA

curator

Community Assessment of Community Annotation with Ontologies

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

determination method

IMP

G protein-coupled receptor signaling pathway

1 reference

24 April 2018

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3U6Q4&geneProductId=UniProtKB:Q3U6Q4

determination method

IDA

positive regulation of MAP kinase activity

1 reference

24 April 2018

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q3U6Q4&geneProductId=UniProtKB:Q3U6Q4

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

determination method

IEA

positive regulation of angiogenesis

3 references

regulation of phosphatidylinositol 3-kinase activity

1 reference

14 February 2019

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

determination method

IEA

phosphatidylinositol 3-kinase signaling

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

determination method

IBA

phosphatidylinositol phosphate biosynthetic process

1 reference

14 February 2019

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q3U6Q4

determination method

IEA

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

(Q21988430)

Phosphoinositide-3-kinase regulatory subunit 5

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