(Q21990391)

http://www.ebi.ac.uk/interpro/protein/P41251

1 reference

25 May 2022

1 reference

25 May 2022

manganese ion transmembrane transporter activity

1 reference

27 March 2018

Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

metal ion transmembrane transporter activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

manganese ion transmembrane transporter activity

cadmium ion transmembrane transporter activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

protein homodimerization activity

3 references

metal ion:proton antiporter activity

iron ion transmembrane transporter activity

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

integral component of membrane

cell component

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

3 references

9 May 2019

Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Identification of a tyrosine-based motif (YGSI) in the amino terminus of Nramp1 (Slc11a1) that is important for lysosomal targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

phagocytic vesicle membrane

6 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

10 September 2018

Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

10 September 2018

Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

10 September 2018

Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

10 September 2018

Nramp1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

1 reference

9 May 2019

Diversity of Ca2+-activated K+ channel transcripts in inner ear hair cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

2 references

1 reference

9 May 2019

Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

phagocytic vesicle membrane

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Nramp1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

The in vivo antibody response against exogenous antigens is not influenced by the mouse Bcg (Nramp1) gene

biological process

interleukin-3 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

response to bacterium

3 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

10 September 2018

Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

response to interferon-gamma

1 reference

9 May 2019

Cell-specific and inducible Nramp1 gene expression in mouse macrophages in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

positive regulation of cytokine production

1 reference

9 May 2019

Contribution of interferon gamma and membrane-associated interleukin 1 to the resistance to murine typhoid of Ityr mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

positive regulation of interferon-gamma production

1 reference

9 May 2019

Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

1 reference

9 May 2019

Delayed cutaneous wound healing in mice lacking solute carrier 11a1 (formerly Nramp1): correlation with decreased expression of secretory leukocyte protease inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

1 reference

9 May 2019

Cloning of porcine NRAMP1 and its induction by lipopolysaccharide, tumor necrosis factor alpha, and interleukin-1beta: role of CD14 and mitogen-activated protein kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

T cell proliferation involved in immune response

ISO

1 reference

9 May 2019

The in vivo antibody response against exogenous antigens is not influenced by the mouse Bcg (Nramp1) gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification

vacuolar acidification

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

1 reference

9 May 2019

Nramp transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: influence on oxidative burst and nitric oxide pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

multicellular organismal iron ion homeostasis

1 reference

9 May 2019

Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

1 reference

9 May 2019

Stabilized expression of mRNA is associated with mycobacterial resistance controlled by Nramp1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

response to lipopolysaccharide

4 references

10 September 2018

Cloning of porcine NRAMP1 and its induction by lipopolysaccharide, tumor necrosis factor alpha, and interleukin-1beta: role of CD14 and mitogen-activated protein kinases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

10 September 2018

Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

10 September 2018

Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

10 September 2018

Cell-specific and inducible Nramp1 gene expression in mouse macrophages in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

antigen processing and presentation of peptide antigen

1 reference

9 May 2019

Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

positive regulation of dendritic cell antigen processing and presentation

1 reference

9 May 2019

Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

positive regulation of gene expression

1 reference

9 May 2019

Delayed cutaneous wound healing in mice lacking solute carrier 11a1 (formerly Nramp1): correlation with decreased expression of secretory leukocyte protease inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

defense response to bacterium

5 references

9 May 2019

Genetic resistance of mice to Mycobacterium paratuberculosis is influenced by Slc11a1 at the early but not at the late stage of infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Contribution of interferon gamma and membrane-associated interleukin 1 to the resistance to murine typhoid of Ityr mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Locating salmonella resistance gene on mouse chromosome 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

positive regulation of T-helper 1 type immune response

1 reference

9 May 2019

Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

MHC class II biosynthetic process

1 reference

9 May 2019

The induction of persistence of I-A expression by macrophages from Bcgr mice occurs via a protein kinase C-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

defense response to Gram-negative bacterium

1 reference

9 May 2019

Genetic control of the innate resistance of mice to Salmonella typhimurium: expression of the Ity gene in peritoneal and splenic macrophages isolated in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

1 reference

9 May 2019

Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane

manganese ion transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

1 reference

9 May 2019

Nramp transfection transfers Ity/Lsh/Bcg-related pleiotropic effects on macrophage activation: influence on oxidative burst and nitric oxide pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

Influence of Slc11a1 (formerly Nramp1) on DSS-induced colitis in mice

inflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

T cell cytokine production

1 reference

9 May 2019

Influence of Slc11a1 (formerly Nramp1) on DSS-induced colitis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

The in vivo antibody response against exogenous antigens is not influenced by the mouse Bcg (Nramp1) gene

interleukin-2 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

negative regulation of cytokine production

1 reference

9 May 2019

Delayed cutaneous wound healing in mice lacking solute carrier 11a1 (formerly Nramp1): correlation with decreased expression of secretory leukocyte protease inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

activation of protein kinase activity

1 reference

9 May 2019

The induction of persistence of I-A expression by macrophages from Bcgr mice occurs via a protein kinase C-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

positive regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

cellular iron ion homeostasis

5 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

10 September 2018

Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

10 September 2018

Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

10 September 2018

Nramp1 equips macrophages for efficient iron recycling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41251&geneProductId=UniProtKB:P41251

defense response to protozoan

3 references

9 May 2019

Natural resistance to infection with intracellular parasites: molecular genetics identifies Nramp1 as the Bcg/Ity/Lsh locus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Regulation of Leishmania populations within the host. II. genetic control of acute susceptibility of mice to Leishmania donovani infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Influence of macrophage resistance gene Lsh/Ity/Bcg (candidate Nramp) on Toxoplasma gondii infection in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

manganese ion transmembrane transport

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

cellular cadmium ion homeostasis

cellular iron ion homeostasis

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Nramp1 equips macrophages for efficient iron recycling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Solute carrier 11a1 (Slc11a1; formerly Nramp1) regulates metabolism and release of iron acquired by phagocytic, but not transferrin-receptor-mediated, iron uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

response to bacterium

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

response to lipopolysaccharide

5 references

9 May 2019

Cloning of porcine NRAMP1 and its induction by lipopolysaccharide, tumor necrosis factor alpha, and interleukin-1beta: role of CD14 and mitogen-activated protein kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Cell-specific and inducible Nramp1 gene expression in mouse macrophages in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251

iron ion transmembrane transport

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41251