(Q22253304)

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Identification of a cryptic nucleolar-localization signal in MDM2

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Identification of a cryptic nucleolar-localization signal in MDM2 (English)

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MDM2 proto-oncogene

1 reference

GOA release 2020-03-11

author name string

M A Lohrum

1

author given names

Marion A. E.

author last names

Lohrum

1 reference

Dimensions Publication ID

7 February 2023

M Ashcroft

2

author given names

Margaret

author last names

Ashcroft

1 reference

Dimensions Publication ID

7 February 2023

M H Kubbutat

3

author given names

Michael H. G.

author last names

Kubbutat

1 reference

Dimensions Publication ID

7 February 2023

K H Vousden

4

author given names

Karen H.

author last names

Vousden

1 reference

Dimensions Publication ID

7 February 2023

language of work or name

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publication date

March 2000

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Nature Cell Biology

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2

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3

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179-81

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Mechanisms of p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2F35004057

7 January 2021

based on heuristic

inferred from DOI database lookup

Keeping an old friend under control: regulation of p53 stability

1 reference

https://api.crossref.org/works/10.1038%2F35004057

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor surveillance via the ARF-p53 pathway.

1 reference

https://api.crossref.org/works/10.1038%2F35004057

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

https://api.crossref.org/works/10.1038%2F35004057

7 January 2021

based on heuristic

inferred from DOI database lookup

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1038%2F35004057

7 January 2021

based on heuristic

inferred from DOI database lookup

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1038%2F35004057

7 January 2021

based on heuristic

inferred from DOI database lookup

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1038%2F35004057

7 January 2021

based on heuristic

inferred from DOI database lookup

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1038%2F35004057

7 January 2021

based on heuristic

inferred from DOI database lookup

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1038%2F35004057

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

1 reference

https://api.crossref.org/works/10.1038%2F35004057

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

https://api.crossref.org/works/10.1038%2F35004057

7 January 2021

based on heuristic

inferred from DOI database lookup

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

1 reference

https://api.crossref.org/works/10.1038%2F35004057

7 January 2021

based on heuristic

inferred from DOI database lookup

p14ARF links the tumour suppressors RB and p53.

1 reference

https://api.crossref.org/works/10.1038%2F35004057

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/35004057

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