(Q22254209)

guanyl-nucleotide exchange factor activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

A M Crompton

1

A M

Crompton

1 reference

29 March 2023

L H Foley

2

L H

Foley

1 reference

29 March 2023

A Wood

3

A

Wood

1 reference

29 March 2023

W Roscoe

4

W

Roscoe

1 reference

29 March 2023

D Stokoe

5

D

Stokoe

1 reference

29 March 2023

F McCormick

6

F

McCormick

1 reference

29 March 2023

M Symons

7

M

Symons

1 reference

29 March 2023

G Bollag

8

G

Journal of Biological Chemistry

Bollag

1 reference

29 March 2023

language of work or name

English

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publication date

18 August 2000

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published in

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volume

275

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page(s)

25751-9

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issue

33

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cites work

Pleckstrin homology domains: a common fold with diverse functions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

An essential role for Rac in Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

A role for Rho in Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Proteins regulating Ras and its relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

A role for Rac in Tiam1-induced membrane ruffling and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Pleckstrin associates with plasma membranes and induces the formation of membrane projections: requirements for phosphorylation and the NH2-terminal PH domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Purification of baculovirus-expressed recombinant Ras and Rap proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Intrinsic and GTPase-activating protein-stimulated Ras GTPase assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Preparation of Standards and Measurement of Nitric Oxide, Nitroxyl, and Related Oxidation Products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Differential regulation of rasGAP and neurofibromatosis gene product activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Protein prenylation: genes, enzymes, targets, and functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

The Dbl family of oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Structure-function relationships of the mouse Gap1m. Determination of the inositol 1,3,4,5-tetrakisphosphate-binding domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Functional interactions of phosphatidylinositol 3-kinase with GTPase-activating protein in 3T3-L1 adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Role of protein-phospholipid interactions in the activation of ARF1 by the guanine nucleotide exchange factor Arno

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200

Invasion of the nucleotide snatchers: structural insights into the mechanism of G protein GEFs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M002050200