(Q2335493)

http://www.ebi.ac.uk/interpro/protein/O00206

InterPro Release 71.0

reference URL

Leucine-rich repeat domain superfamily

1 reference

http://www.ebi.ac.uk/interpro/protein/O00206

InterPro Release 71.0

reference URL

NEAT-domain containing methaemoglobin heme sequestration family

1 reference

Transporter Classification Database ID

8.A.43.1.9

2 October 2019

hierarchical database ID heuristic

Toll/interleukin-1 receptor homology (TIR) domain, protein family

1 reference

Cysteine-rich flanking region, C-terminal domain, protein family

1 reference

Leucine-rich repeat, typical subtype, protein family

1 reference

Leucine-rich repeat, protein family

1 reference

lipopolysaccharide immune receptor activity

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

5 August 2016

lipopolysaccharide binding

1 reference

5 August 2016

1 reference

5 August 2016

transmembrane signaling receptor activity

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

perinuclear region of cytoplasm

1 reference

5 August 2016

1 reference

5 August 2016

integral component of membrane

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

intrinsic component of plasma membrane

1 reference

5 August 2016

integral component of plasma membrane

1 reference

5 August 2016

lipopolysaccharide receptor complex

1 reference

5 August 2016

external side of plasma membrane

1 reference

5 August 2016

positive regulation of MHC class II biosynthetic process

biological process

1 reference

5 August 2016

positive regulation of JNK cascade

1 reference

5 August 2016

TRIF-dependent toll-like receptor signaling pathway

1 reference

5 August 2016

cellular response to mechanical stimulus

1 reference

5 August 2016

positive regulation of interleukin-8 production

1 reference

5 August 2016

positive regulation of ERK1 and ERK2 cascade

1 reference

5 August 2016

T-helper 1 type immune response

1 reference

5 August 2016

positive regulation of platelet activation

1 reference

5 August 2016

positive regulation of interleukin-1 production

1 reference

5 August 2016

positive regulation of stress-activated MAPK cascade

1 reference

5 August 2016

positive regulation of NLRP3 inflammasome complex assembly

1 reference

5 August 2016

positive regulation of interleukin-12 production

1 reference

5 August 2016

positive regulation of interferon-alpha production

1 reference

5 August 2016

I-kappaB phosphorylation

1 reference

5 August 2016

positive regulation of nitric-oxide synthase biosynthetic process

1 reference

5 August 2016

positive regulation of B cell proliferation

1 reference

5 August 2016

defense response to bacterium

1 reference

5 August 2016

positive regulation of interleukin-6 production

1 reference

5 August 2016

activation of innate immune response

1 reference

5 August 2016

positive regulation of tumor necrosis factor production

1 reference

5 August 2016

negative regulation of tumor necrosis factor production

1 reference

5 August 2016

innate immune response

1 reference

5 August 2016

negative regulation of interleukin-17 production

1 reference

5 August 2016

I-kappaB kinase/NF-kappaB signaling

1 reference

5 August 2016

positive regulation of interferon-beta production

1 reference

5 August 2016

positive regulation of inflammatory response

1 reference

5 August 2016

toll-like receptor 4 signaling pathway

1 reference

5 August 2016

positive regulation of macrophage cytokine production

1 reference

5 August 2016

positive regulation of interleukin-10 production

1 reference

5 August 2016

immune system process

1 reference

5 August 2016

astrocyte development

1 reference

5 August 2016

intestinal epithelial structure maintenance

1 reference

5 August 2016

positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

1 reference

5 August 2016

response to lipopolysaccharide

1 reference

5 August 2016

cellular response to lipoteichoic acid

1 reference

5 August 2016

positive regulation of NF-kappaB transcription factor activity

1 reference

5 August 2016

1 reference

5 August 2016

negative regulation of interleukin-23 production

1 reference

5 August 2016

regulation of inflammatory response

1 reference

5 August 2016

positive regulation of chemokine production

1 reference

5 August 2016

lipopolysaccharide-mediated signaling pathway

1 reference

5 August 2016

1 reference

5 August 2016

positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

1 reference

5 August 2016

negative regulation of interferon-gamma production

1 reference

5 August 2016

response to bacterium

1 reference

5 August 2016

negative regulation of osteoclast differentiation

1 reference

5 August 2016

B cell proliferation involved in immune response

1 reference

5 August 2016

positive regulation of nitric oxide biosynthetic process

1 reference

5 August 2016

negative regulation of interleukin-6 production

1 reference

5 August 2016

positive regulation of interferon-gamma production

1 reference

5 August 2016

nitric oxide production involved in inflammatory response

1 reference

5 August 2016

MyD88-dependent toll-like receptor signaling pathway

1 reference

5 August 2016

regulation of dendritic cell cytokine production

1 reference

5 August 2016

positive regulation of gene expression

1 reference

5 August 2016

negative regulation of ERK1 and ERK2 cascade

1 reference

5 August 2016

positive regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

5 August 2016

macrophage activation

1 reference

5 August 2016

detection of lipopolysaccharide

1 reference

5 August 2016

cellular response to lipopolysaccharide

1 reference

5 August 2016

positive regulation of lymphocyte proliferation

1 reference

5 August 2016

positive regulation of transcription by RNA polymerase II

1 reference

5 August 2016

MyD88-independent toll-like receptor signaling pathway

1 reference

5 August 2016

1 reference

5 August 2016

inflammatory response

1 reference

5 August 2016

defense response to Gram-negative bacterium

1 reference

5 August 2016

toll-like receptor signaling pathway

1 reference

5 August 2016

1 reference

5 August 2016

apoptotic signaling pathway

1 reference

5 August 2016

negative regulation of MyD88-independent toll-like receptor signaling pathway

1 reference

5 August 2016

physically interacts with

1 reference

Open Targets Platform

https://platform.opentargets.org/drug/CHEMBL225157

14 August 2023

reference URL

Identifiers

MeSH descriptor ID

D051197

subject named as

Toll-Like Receptor 4

0 references

MeSH tree code

D12.776.543.750.705.910.500.400

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

28 October 2013

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

Transporter Classification Database ID

8.A.43.1.9

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023