(Q23671272)

ABT-199 (English)

3 October 2016

C₄₅H₅₀ClN₇O₇S

1 reference

ABT-199 (English)

20 November 2016

CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C

1 reference

European Medicines Agency product number

ABT-199 (English)

20 November 2016

1 reference

EMEA/H/C/004106

reference URL

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/004106/human_med_002045.jsp

22 March 2017

1 reference

14 February 2018

medical condition treated

mantle cell lymphoma

1 reference

chronic lymphocytic leukemia

2 October 2018

1 reference

2 October 2018

acute myeloid leukemia

1 reference

2 October 2018

myelodysplastic syndrome

1 reference

2 October 2018

non-Hodgkin lymphoma

1 reference

2 October 2018

B-cell lymphoma

1 reference

diffuse large B-cell lymphoma

2 October 2018

1 reference

chronic lymphocytic leukemia

2 October 2018

start time

11 April 2016

approved by

Food and Drug Administration

1 reference

Inxight: Drugs Database

https://drugs.ncats.io/drug/N54AIC43PW

2 November 2018

reference URL

http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/208573s000lbl.pdf

physically interacts with

BCL2 apoptosis regulator

subject has role

reaction inhibitor

1 reference

Open Targets Platform

https://platform.opentargets.org/drug/CHEMBL3137309

14 August 2023

reference URL

LiverTox likelihood score

LiverTox toxicity likelihood category E

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Venetoclax

last update

4 April 2017

subject has role

xenobiotic-transporting ATPase inhibitor

1 reference

5 March 2018

1 reference

Medical Subject Headings

15 March 2018

Venetoclax

0 references

Identifiers

InChI

InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54)

1 reference

LQBVNQSMGBZMKD-UHFFFAOYSA-N

ABT-199 (English)

20 November 2016

2 references

ABT-199 (English)

20 November 2016

ChEBI release 2020-09-01

CAS Registry Number

1257044-40-8

2 references

Global Substance Registration System

UNII

N54AIC43PW

LQBVNQSMGBZMKD-UHFFFAOYSA-N

venetoclax (English)

20 November 2016

8 April 2021

https://commonchemistry.cas.org/detail?cas_rn=1257044-40-8

1 reference

Venetoclax (English)

20 November 2016

1 reference

ABT-199 (English)

20 November 2016

mapping relation type

exact match

1 reference

ChEBI release 2019-10-02

1 reference

Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard

VENETOCLAX (English)

20 November 2016

1 reference

1 reference

DSSTOX compound identifier

0 references

0 references

820-130-9

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.254.611

ECHA Substance Infocard ID

27 December 2018

title

2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide (amorphous) (English)

quotation

CAS no.: 1257044-40-8 (English)

100.254.611

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.254.611

Guide to Pharmacology Ligand ID

27 December 2018

title

2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide (amorphous) (English)

quotation

CAS no.: 1257044-40-8 (English)

ATC code

L01XX52

0 references

8318

1 reference