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MEN2A-RET-induced cellular transformation by activation of STAT3
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title
MEN2A-RET-induced cellular transformation by activation of STAT3
(English)
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author
Robert Hofstra
series ordinal
6
object named as
R Hofstra
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author name string
J J Schuringa
series ordinal
1
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K Wojtachnio
series ordinal
2
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W Hagens
series ordinal
3
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E Vellenga
series ordinal
4
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C H Buys
series ordinal
5
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W Kruijer
series ordinal
7
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language of work or name
English
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publication date
30 August 2001
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published in
Oncogene
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volume
20
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page(s)
5350-8
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issue
38
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cites work
Grb2 binding to the different isoforms of Ret tyrosine kinase.
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
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inferred from DOI database lookup
Identification of Shc docking site on Ret tyrosine kinase
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
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inferred from DOI database lookup
A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
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inferred from DOI database lookup
The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
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inferred from DOI database lookup
STATs in oncogenesis
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stat3 activation is required for cellular transformation by v-src
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
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Stat3 as an oncogene
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
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STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
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Activation and association of Stat3 with Src in v-Src-transformed cell lines
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
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inferred from DOI database lookup
The role of STATs in myeloid differentiation and leukemia
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
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Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: dependence on cyclic AMP-inducible elements
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
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Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC.
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
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Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
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inferred from DOI database lookup
STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RET gene and its implications for cancer
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
based on heuristic
inferred from DOI database lookup
Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
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Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
STATs: signal transducers and activators of transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
STAT signaling in the pathogenesis and treatment of leukemias
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncogenic activation of RET by two distinct FMTC mutations affecting the tyrosine kinase domain.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional responses to polypeptide ligands: the JAK-STAT pathway
1 reference
stated in
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
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7 January 2021
based on heuristic
inferred from DOI database lookup
Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
STAT signaling in head and neck cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ret transforming gene encodes a fusion protein homologous to tyrosine kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stat3 activation by Src induces specific gene regulation and is required for cell transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stat3 plays an important role in oncogenic Ros- and insulin-like growth factor I receptor-induced anchorage-independent growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1204715
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.ONC.1204715
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Dimensions Publication ID
1015611027
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PubMed ID
11536047
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ResearchGate publication ID
11810462
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Springer Nature article ID
10.1038/sj.onc.1204715
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