(Q24296637)

English

Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation

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scholarly article

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Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation (English)

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apoptotic process

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author name string

Lina Pan

1

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Ammar F Matloob

2

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Juan Du

3

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Hong Pan

4

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Zhixiong Dong

5

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Jing Zhao

6

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Yu Feng

7

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Yun Zhong

8

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Baiqu Huang

9

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Jun Lu

10

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language of work or name

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publication date

February 2010

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277

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989-99

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4

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Helicobacter pylori and gastrointestinal tract adenocarcinomas

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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Gastric carcinoma

1 reference

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Chemotherapy of advanced gastric cancer

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Molecular tools for study of genomic and rapid signal transduction responses initiated by 1 alpha,25(OH)(2)-vitamin D(3).

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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Regulation of PTEN transcription by p53

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Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.

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The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

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Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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Suppression of PTEN expression by NF-kappa B prevents apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines

1 reference

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Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer

1 reference

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DNA methylation and cancer

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Resistance to Imatinib Mesylate-induced apoptosis in acute lymphoblastic leukemia is associated with PTEN down-regulation due to promoter hypermethylation

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Hypermethylation of the PTEN gene in ovarian cancer cell lines

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Mammalian target of rapamycin pathway inhibition enhances the effects of 5-aza-dC on suppressing cell proliferation in human gastric cancer cell lines

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Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2'-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells

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Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer

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Targeting tumor angiogenesis with histone deacetylase inhibitors: the hydroxamic acid derivative LBH589.

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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Promoter methylation and silencing of PTEN in gastric carcinoma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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Reduced PTEN expression in gastric cancer and in the gastric mucosa of gastric cancer relatives

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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Vitamin D deficiency

1 reference

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Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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Involvement of the vitamin D receptor in the regulation of NF-kappaB activity in fibroblasts

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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Control of phosphatase and tensin homolog (PTEN) gene expression in normal and neoplastic thyroid cells

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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Recruitment of histone deacetylase 4 by transcription factors represses interleukin-5 transcription

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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Methylation of CpG islands of p16 associated with progression of primary gastric carcinomas

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

7 January 2021

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The fundamental role of epigenetic events in cancer

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based on heuristic

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Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

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Overview of general physiologic features and functions of vitamin D.

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Aberrant methylation of multiple genes in gastric carcinomas

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07542.X

7 January 2021

based on heuristic

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Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells

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based on heuristic

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