(Q24298263)

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Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation

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30 December 2019

Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation (English)

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30 December 2019

Eukaryotic translation initiation factor 2 alpha kinase 2

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GOA release 2020-03-11

protein kinase activity

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GOA release 2020-03-11

6

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30 December 2019

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Aristóbolo M Silva

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30 December 2019

Mark Whitmore

2

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30 December 2019

Zan Xu

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30 December 2019

Zhengfan Jiang

4

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30 December 2019

Xiaoxia Li

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30 December 2019

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30 June 2004

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30 December 2019

Journal of Biological Chemistry

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30 December 2019

279

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30 December 2019

37670-37676

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30 December 2019

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30 December 2019

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

TIRAP: an adapter molecule in the Toll signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

PKR; a sentinel kinase for cellular stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1. Implications for apoptosis signaling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of the structure and function of a novel MAP kinase kinase (MKK6)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of the solution complex between the interferon-induced, double-stranded RNA-activated protein kinase and HIV-I trans-activating region RNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

MEK kinase 3 directly activates MKK6 and MKK7, specific activators of the p38 and c-Jun NH2-terminal kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

2-Aminopurine inhibits the double-stranded RNA-dependent protein kinase both in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

PACT, a protein activator of the interferon-induced protein kinase, PKR.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

2-Aminopurine selectively blocks the transcriptional activation of cellular genes by virus, double-stranded RNA and interferons in human cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

A mammalian scaffold complex that selectively mediates MAP kinase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Double-stranded RNA-dependent protein kinase and 2-5A system are both activated in interferon-treated, encephalomyocarditis virus-infected HeLa cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)-terminal kinase by double-stranded RNA and encephalomyocarditis virus: involvement of RNase L, protein kinase R, and alternative pathways.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

High-efficiency transformation of mammalian cells by plasmid DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406554200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1074/JBC.M406554200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15229216%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15229216%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

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