(Q24300271)

regulation of focal adhesion assembly

GOA release 2020-03-11

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Current Opinion in Cell Biology

GOA release 2020-03-11

author name string

Satyajit K Mitra

series ordinal

1

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David D Schlaepfer

series ordinal

2

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language of work or name

English

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publication date

October 2006

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published in

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volume

18

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page(s)

516-23

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issue

5

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cites work

Molecular basis for regulation of Src by the docking protein p130Cas

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Integrin signaling in malignant melanoma.

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Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites

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Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold.

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Control of motile and invasive cell phenotypes by focal adhesion kinase.

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Src kinase regulation by phosphorylation and dephosphorylation

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A truncated FAK lacking the FERM domain displays high catalytic activity but retains responsiveness to adhesion-mediated signals

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Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2

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Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction.

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Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition.

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FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation

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Multiple connections link FAK to cell motility and invasion

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Integrins and Src: dynamic duo of adhesion signaling

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Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion

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FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies

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7 January 2021

FAK regulates biological processes important for the pathogenesis of cancer

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FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

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7 January 2021

Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase

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The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

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Integrin signalling during tumour progression

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Focal adhesion kinase: in command and control of cell motility

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CAS promotes invasiveness of Src-transformed cells

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The interplay between Src and integrins in normal and tumor biology

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The p53 pathway: positive and negative feedback loops

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Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK.

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Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model.

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Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function.

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7 January 2021

Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors

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7 January 2021

CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas

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7 January 2021

Src kinase activation by direct interaction with the integrin β cytoplasmic domain

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7 January 2021

Focal adhesion kinase regulation of N-WASP subcellular localization and function

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7 January 2021

Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts

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7 January 2021

p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain

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7 January 2021

Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation.

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7 January 2021

Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53

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7 January 2021

Deregulation of proteasome function induces Abl-mediated cell death by uncoupling p130CAS and c-CrkII.

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7 January 2021

Crystal structure of the FERM domain of focal adhesion kinase.

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7 January 2021

Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration

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7 January 2021

Integrin-induced tyrosine phosphorylation of protein-tyrosine phosphatase-alpha is required for cytoskeletal reorganization and cell migration.

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https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

Differential regulation of cell motility and invasion by FAK

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7 January 2021

The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration

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7 January 2021

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis

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7 January 2021

FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion

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7 January 2021

FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration.

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https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

A novel mode for integrin-mediated signaling: tethering is required for phosphorylation of FAK Y397

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7 January 2021

P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading

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https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness

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https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

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7 January 2021

Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling

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https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

Alternative splicing controls the mechanisms of FAK autophosphorylation

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https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior

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https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation

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https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

Mechanism of cell cycle regulation by FIP200 in human breast cancer cells

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https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

Treatment for advanced tumors: SRC reclaims center stage

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https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization

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https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

Mechanisms of focal adhesion kinase regulation

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https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021

Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model

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https://api.crossref.org/works/10.1016%2FJ.CEB.2006.08.011

7 January 2021