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IRAK-M is a negative regulator of Toll-like receptor signaling
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scholarly article
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title
IRAK-M is a negative regulator of Toll-like receptor signaling
(English)
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main subject
toll-like receptor
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Interleukin 1 receptor associated kinase 3
1 reference
stated in
GOA release 2020-03-11
negative regulation of innate immune response
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stated in
GOA release 2020-03-11
Interleukin-1 receptor-associated kinase 3
1 reference
stated in
GOA release 2020-03-11
author
Ruslan Medzhitov
series ordinal
5
object named as
Ruslan Medzhitov
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Richard Flavell
series ordinal
6
object named as
Richard A Flavell
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author name string
Koichi Kobayashi
series ordinal
1
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Lorraine D Hernandez
series ordinal
2
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Jorge E Galán
series ordinal
3
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Charles A Janeway
series ordinal
4
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language of work or name
English
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publication date
26 July 2002
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published in
Cell
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volume
110
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page(s)
191-202
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issue
2
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cites work
Toll-like receptors: critical proteins linking innate and acquired immunity
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Crossref
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7 January 2021
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Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
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TOLERANCE TO BACTERIAL PYROGENS : I. FACTORS INFLUENCING ITS DEVELOPMENT.
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Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin
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Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
1 reference
stated in
Crossref
reference URL
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7 January 2021
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IRAK: a kinase associated with the interleukin-1 receptor
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Crossref
reference URL
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Evidence for a gamma-interferon receptor that regulates macrophage tumoricidal activity
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Salmonella spp. are cytotoxic for cultured macrophages.
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The importance of a lipopolysaccharide-initiated, cytokine-mediated host defense mechanism in mice against extraintestinally invasive Escherichia coli
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Endotoxemia in human septic shock
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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
1 reference
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reference URL
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Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells
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Hyporesponsiveness to lipopolysaccharide alters the composition of NF-kappaB binding to the regulatory regions of inducible nitric oxide synthase gene
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Mechanisms of endotoxin tolerance. IV. Specificity of the pyrogenic refractory state during continuous intravenous infusions of endotoxin
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reference URL
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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
1 reference
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A Toll-like receptor recognizes bacterial DNA
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reference URL
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7 January 2021
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inferred from DOI database lookup
TIRAP: an adapter molecule in the Toll signaling pathway
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reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900827-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900827-9
retrieved
7 January 2021
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inferred from DOI database lookup
The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PulD family of proteins.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900827-9
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7 January 2021
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inferred from DOI database lookup
Unresponsiveness of MyD88-deficient mice to endotoxin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900827-9
retrieved
7 January 2021
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inferred from DOI database lookup
Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity
1 reference
stated in
Crossref
reference URL
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7 January 2021
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Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation
1 reference
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Crossref
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Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells
1 reference
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Crossref
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Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase
1 reference
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Crossref
reference URL
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IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-κB
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inferred from DOI database lookup
A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types
1 reference
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Innate immunity: the virtues of a nonclonal system of recognition
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Crossref
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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900827-9
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inferred from DOI database lookup
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Non-invasive Salmonella typhimurium mutants are avirulent because of an inability to enter and destroy M cells of ileal Peyer's patches
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900827-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Pulmonary and hepatic gene expression following cecal ligation and puncture: monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration
1 reference
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Crossref
reference URL
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inferred from DOI database lookup
Toll-like receptors control activation of adaptive immune responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900827-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900827-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900827-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
1 reference
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Crossref
reference URL
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Crohn's disease: genetic susceptibility, bacteria, and innate immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900827-9
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7 January 2021
based on heuristic
inferred from DOI database lookup
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900827-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900827-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900827-9
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900827-9
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7 January 2021
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Identifiers
DOI
10.1016/S0092-8674(02)00827-9
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1035365
OpenCitations bibliographic resource ID
1035365
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1035365
PubMed ID
12150927
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1035365
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