(Q24306239)

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LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations

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LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations (English)

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Parkinson's disease

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based on heuristic

inferred from title

phosphorylation

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author name string

Etsuro Ohta

1

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Fumitaka Kawakami

2

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Makoto Kubo

3

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Fumiya Obata

4

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language of work or name

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publication date

21 July 2011

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585

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2165-70

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14

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A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

The RIP kinases: crucial integrators of cellular stress

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Identification of the autophosphorylation sites of LRRK2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

AKT/PKB signaling: navigating downstream

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Biochemical characterization of phospholipids, sulfatide and heparin as potent stimulators for autophosphorylation of GSK-3beta and the GSK-3beta-mediated phosphorylation of myelin basic protein in vitro

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

LRRK2 is involved in the IFN-gamma response and host response to pathogens

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Kinase activity of mutant LRRK2 mediates neuronal toxicity

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Apoptotic mechanisms in mutant LRRK2-mediated cell death

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.05.044

21 January 2018

Identifiers

10.1016/J.FEBSLET.2011.05.044

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Consolidated OpenCitations Corpus – April 2017

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release_r4uoxomyy5hcllkvwrfcnzkiiy

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https://api.fatcat.wiki/v0/release/r4uoxomyy5hcllkvwrfcnzkiiy

24 November 2022

based on heuristic

mapped directly with Wikidata item

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

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