(Q24313505)

1

Marina Konopleva

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Michael Andreeff

26

Michael Andreeff

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Peter P Ruvolo

5

Peter P Ruvolo

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Teresa S McQueen

14

Teresa McQueen

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Wendy D Schober

15

Wendy D Schober

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James A. McCubrey

23

James McCubrey

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Rooha Contractor

2

Rooha Contractor

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Twee Tsao

3

Twee Tsao

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Ismael Samudio

4

Ismael Samudio

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Vivian Ruvolo

13

Vivian R Ruvolo

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Julie A Watts

16

Julie C Watt

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Tilahun Jiffar

17

Tilahun Jiffar

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Xiaoyang Ling

18

Xiaoyang Ling

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Frank Marini

19

Frank C Marini

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author name string

Shinichi Kitada

6

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Xingming Deng

7

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Dayong Zhai

8

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Yue-Xi Shi

9

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Thomas Sneed

10

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Monique Verhaegen

11

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Maria Soengas

12

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David Harris

20

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Martin Dietrich

21

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W Stratford May

24

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John C Reed

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

25

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language of work or name

English

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publication date

November 2006

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published in

Cancer Cell

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volume

10

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page(s)

375-88

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issue

5

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cites work

1 reference

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7 January 2021

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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7 January 2021

Control of mitochondrial permeability by Bcl-2 family members

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7 January 2021

Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.

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7 January 2021

Killing cancer cells by flipping the Bcl-2/Bax switch.

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7 January 2021

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

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7 January 2021

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

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https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Distinct domains of Bcl-XL are involved in Bax and Bad antagonism and in apoptosis inhibition

1 reference

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7 January 2021

Insights into programmed cell death through structural biology

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https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

1 reference

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7 January 2021

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid

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https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Bcl2 phosphorylation and active PKC alpha are associated with poor survival in AML.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and phosphatidylinositol 3-kinase in the regulation of Mcl-1 synthesis

1 reference

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7 January 2021

In vivo suppression of Bcl-XL expression facilitates chemotherapy-induced leukaemia cell death in a SCID/NOD-Hu model

1 reference

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7 January 2021

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Bcl-2 phosphorylation required for anti-apoptosis function

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Nonionic detergents induce dimerization among members of the Bcl-2 family

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https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Disruption of Mcl-1.Bim complex in granzyme B-mediated mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Movement of Bax from the cytosol to mitochondria during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Development of a self-inactivating lentivirus vector.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Bcl2's flexible loop domain regulates p53 binding and survival

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https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Development of a conditional in vivo model to evaluate the efficacy of small molecule inhibitors for the treatment of Raf-transformed hematopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021

Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CCR.2006.10.006

7 January 2021