(Q24315679)

Ribosomal protein S6 kinase A3

GOA release 2020-03-11

1 reference

positive regulation of cell differentiation

GOA release 2020-03-11

1 reference

Nature Reviews Molecular Cell Biology

GOA release 2020-03-11

author name string

Rana Anjum

series ordinal

1

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John Blenis

series ordinal

2

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language of work or name

English

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publication date

October 2008

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published in

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volume

9

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page(s)

747-58

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issue

10

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cites work

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

1 reference

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

31 March 2020

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The RSK factors of activating the Ras/MAPK signaling cascade

31 March 2020

1 reference

A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases

31 March 2020

1 reference

Evidence for two catalytically active kinase domains in pp90rsk

31 March 2020

1 reference

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

31 March 2020

1 reference

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

31 March 2020

1 reference

RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)

31 March 2020

1 reference

Increased phosphorylation of ribosomal protein S6 during meiotic maturation of Xenopus oocytes

31 March 2020

1 reference

A protein kinase from Xenopus eggs specific for ribosomal protein S6.

31 March 2020

1 reference

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

31 March 2020

1 reference

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

31 March 2020

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

31 March 2020

1 reference

p70(S6K) controls selective mRNA translation during oocyte maturation and early embryogenesis in Xenopus laevis

31 March 2020

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RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

31 March 2020

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Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1

31 March 2020

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Molecular interpretation of ERK signal duration by immediate early gene products

31 March 2020

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Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.

31 March 2020

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RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation

31 March 2020

1 reference

Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin-Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning

31 March 2020

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Divergent functional roles for p90rsk kinase domains

31 March 2020

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Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity

31 March 2020

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A p90(rsk) mutant constitutively interacting with MAP kinase uncouples MAP kinase from p34(cdc2)/cyclin B activation in Xenopus oocytes

31 March 2020

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Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK

31 March 2020

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90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

31 March 2020

1 reference

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

31 March 2020

1 reference

PDK1, the master regulator of AGC kinase signal transduction

31 March 2020

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MSK1 activity is controlled by multiple phosphorylation sites.

31 March 2020

1 reference

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

31 March 2020

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A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

31 March 2020

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Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

31 March 2020

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A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

31 March 2020

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Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK.

31 March 2020

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Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase

31 March 2020

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Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo

31 March 2020

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The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways

31 March 2020

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The MAP kinase ERK5 binds to and phosphorylates p90 RSK.

31 March 2020

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FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway

31 March 2020

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ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

31 March 2020

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p90 ribosomal S6 kinase 2 is associated with and dephosphorylated by protein phosphatase 2Cdelta

31 March 2020

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Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development

31 March 2020

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Subcellular localization and biological actions of activated RSK1 are determined by its interactions with subunits of cyclic AMP-dependent protein kinase

31 March 2020

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Comparison of the specificities of p70 S6 kinase and MAPKAP kinase-1 identifies a relatively specific substrate for p70 S6 kinase: the N-terminal kinase domain of MAPKAP kinase-1 is essential for peptide phosphorylation

31 March 2020

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Gene silencing in mammals by small interfering RNAs

31 March 2020

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Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome

31 March 2020

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Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.

31 March 2020

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Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene

31 March 2020

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Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene

31 March 2020

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MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells

31 March 2020

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Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase

31 March 2020

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Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation.

31 March 2020

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The signal-dependent coactivator CBP is a nuclear target for pp90RSK

31 March 2020

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pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167

31 March 2020

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Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A

31 March 2020

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ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.

31 March 2020

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Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling

31 March 2020

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

31 March 2020

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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

31 March 2020

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Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.

31 March 2020

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Signaling control of mRNA translation in cancer pathogenesis

31 March 2020

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Metabotropic glutamate receptor-initiated translocation of protein kinase p90rsk to polyribosomes: a possible factor regulating synaptic protein synthesis

31 March 2020

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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

31 March 2020

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AKT/PKB signaling: navigating downstream

31 March 2020

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Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation

31 March 2020

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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

31 March 2020

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Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F

31 March 2020

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mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

31 March 2020

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Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

31 March 2020

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S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

31 March 2020

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31 March 2020

The renaissance of GSK3

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Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

31 March 2020

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Rsk1 mediates a MEK-MAP kinase cell survival signal

31 March 2020

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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

31 March 2020

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p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway

31 March 2020

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The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling

31 March 2020

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C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival

31 March 2020

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Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB.

31 March 2020

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Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase

31 March 2020

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The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro

31 March 2020

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IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase

31 March 2020

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Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization

31 March 2020

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Regulation of the meiotic cell cycle in oocytes

31 March 2020

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A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1.

31 March 2020

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The protein kinase p90 rsk as an essential mediator of cytostatic factor activity.

31 March 2020

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Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase p90Rsk.

31 March 2020

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Bub1 is activated by the protein kinase p90(Rsk) during Xenopus oocyte maturation

31 March 2020

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A direct link of the Mos-MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus laevis eggs.

31 March 2020

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Phosphorylation of Erp1 by p90rsk is required for cytostatic factor arrest in Xenopus laevis eggs.

31 March 2020

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Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site

31 March 2020

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Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1

31 March 2020

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Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport

31 March 2020

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p90 RSK-1 associates with and inhibits neuronal nitric oxide synthase.

31 March 2020

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p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1

31 March 2020

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Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR.

31 March 2020

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Activation of p90 Rsk1 is sufficient for differentiation of PC12 cells

31 March 2020

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RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer

31 March 2020

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

31 March 2020

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Aberrant expression of X-linked genes RbAp46, Rsk4, and Cldn2 in breast cancer

31 March 2020

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Characterization of mouse Rsk4 as an inhibitor of fibroblast growth factor-RAS-extracellular signal-regulated kinase signaling

31 March 2020

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Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss

31 March 2020

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The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation

31 March 2020

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Structural bioinformatics-based design of selective, irreversible kinase inhibitors

31 March 2020

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BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

31 March 2020

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The selectivity of protein kinase inhibitors: a further update

31 March 2020

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p90Rsk is not involved in cytostatic factor arrest in mouse oocytes

31 March 2020

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Altered extracellular signal-regulated kinase signaling and glycogen metabolism in skeletal muscle from p90 ribosomal S6 kinase 2 knockout mice

31 March 2020

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Deletion of the Coffin-Lowry syndrome gene Rsk2 in mice is associated with impaired spatial learning and reduced control of exploratory behavior

31 March 2020

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Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2.

31 March 2020

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The S6KII (rsk) gene of Drosophila melanogaster differentially affects an operant and a classical learning task.

31 March 2020

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C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB)

31 March 2020

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MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts

31 March 2020

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MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14

31 March 2020

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Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins.

31 March 2020

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The kinase MSK1 is required for induction of c-fos by lysophosphatidic acid in mouse embryonic stem cells

31 March 2020

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A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation

31 March 2020

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Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo

31 March 2020

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Phosphorylation of the ribosomal protein S6 is elevated in cells transformed by a variety of tumor viruses

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer

1 reference