(Q24320119)

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Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress

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Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress (English)

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Solute carrier family 6 member 3

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GOA release 2020-03-11

Synuclein alpha

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GOA release 2020-03-11

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based on heuristic

inferred from title

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author name string

Christophe Wersinger

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Delphine Prou

2

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Philippe Vernier

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Anita Sidhu

4

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language of work or name

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publication date

November 2003

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17

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2151-3

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14

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Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Synphilin-1 is present in Lewy bodies in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Age-dependent differential regulation of genes encoding APP and alpha-synuclein in hippocampal synaptic plasticity

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunocytochemical localization of the dopamine transporter in human brain

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Review: formation and properties of amyloid-like fibrils derived from alpha-synuclein and related proteins

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha-synuclein and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

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A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunohistochemical comparison of alpha- and beta-synuclein in adult rat central nervous system

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure and function of the dopamine transporter

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple-system atrophy: a new alpha-synuclein disease?

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic and acute regulation of Na+/Cl- -dependent neurotransmitter transporters: drugs, substrates, presynaptic receptors, and signaling systems

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Abnormal patterns of microtubule-associated protein-2 (MAP-2) immunolabeling in neuronal nuclei and Lewy bodies in Parkinson's disease substantia nigra brain tissues.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of cell death by alpha-synuclein is stimulus-dependent in mammalian cells

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Attenuation of dopamine transporter activity by alpha-synuclein

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential cytotoxicity of dopamine and H2O2 in a human neuroblastoma divided cell line transfected with α-synuclein and its familial Parkinson's disease-linked mutants

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Synuclein expression is decreased in rat substantia nigra following induction of apoptosis by intrastriatal 6-hydroxydopamine.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Filamentous nerve cell inclusions in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in the lipid-binding domain of α-synuclein confer overlapping, yet distinct, functional properties in the regulation of dopamine transporter activity

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Lewy body diseases and multiple system atrophy as alpha-synucleinopathies.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased expression of rat synuclein in the substantia nigra pars compacta identified by mRNA differential display in a model of developmental target injury.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Tubulin seeds alpha-synuclein fibril formation

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

The synuclein family

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of parkinson's disease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Absence of mutations in the coding region of the alpha-synuclein gene in pathologically proven Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Recent advances in the genetics and pathogenesis of Parkinson disease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

A role for alpha-synuclein in the regulation of dopamine biosynthesis

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

The control of dopamine neuron development, function and survival: insights from transgenic mice and the relevance to human disease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.03-0152FJE

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1096/FJ.03-0152FJE

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