(Q24559913)

English

Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative

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Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative (English)

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author name string

L Singh

1

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A E Donald

2

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A C Foster

3

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P H Hutson

4

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L L Iversen

5

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S D Iversen

6

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J A Kemp

7

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P D Leeson

8

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G R Marshall

9

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R J Oles

10

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language of work or name

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publication date

January 1990

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Proceedings of the National Academy of Sciences of the United States of America

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87

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347-51

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1

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1‐Hydroxy‐3‐amino‐pyrrolidone‐2 (HA‐966): a new GABA‐like compound, with potential use in extrapyramidal diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=53260

24 March 2017

Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=53260

24 March 2017

7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=53260

24 March 2017

Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=53260

27 September 2017

3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=53260

27 September 2017

Mg2+-like selective antagonism of excitatory amino acid-induced responses by α,ε-diaminopimelic acid, D-α-maminoadipate and HA-966 in isolated spinal cord of frog and immature rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=53260

27 September 2017

Dopaminergic neurons: similar biochemical and histochemical effects of gamma-hydroxybutyrate and acute lesions of the nigro-neostriatal pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=53260

30 May 2018

Phencyclidine-like discriminative stimulus properties of MK-801 in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=53260

30 May 2018

The discriminative stimulus effects of N-methyl-D-aspartate antagonists in phencyclidine-trained rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=53260

30 May 2018

Glycine modulates [3H]MK-801 binding to the NMDA receptor in rat brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=53260

30 May 2018

A role for receptors of N-methyl-D-aspartic acid in the discriminative stimulus properties of phencyclidine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=53260

30 May 2018

The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=53260

30 May 2018

HA-966 antagonizes N-methyl-D-aspartate receptors through a selective interaction with the glycine modulatory site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=53260

30 May 2018

Biochemical evidence that glycine allosterically regulates an NMDA receptor-coupled ion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=53260

28 November 2018

Differential effects of acute and subacute HA-966 treatment on storage and release of striatal dopamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/2153294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycine potentiates the NMDA response in cultured mouse brain neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/2153294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phosphonovalerate (D-AP5) on rat cortical slices

1 reference

https://pubmed.ncbi.nlm.nih.gov/2153294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycine potentiates strychnine-induced convulsions: role of NMDA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/2153294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OHDPAT into the nucleus raphe dorsalis

1 reference

https://pubmed.ncbi.nlm.nih.gov/2153294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.87.1.347

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1990PNAS...87..347S

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release_iphpxovujja2hgvyomychpnhtu

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https://api.fatcat.wiki/v0/release/iphpxovujja2hgvyomychpnhtu

24 November 2022

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mapped directly with Wikidata item

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