(Q24568252)

English

Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin

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25 October 2019

Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin (English)

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25 October 2019

Hans-Dieter Klenk

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H D Klenk

Klenk HD

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25 October 2019

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Schäfer W

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25 October 2019

Stroh A

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25 October 2019

Berghöfer S

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25 October 2019

Seiler J

4

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25 October 2019

Vey M

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25 October 2019

Kruse ML

6

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25 October 2019

Kern HF

7

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25 October 2019

Garten W

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25 October 2019

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1 June 1995

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25 October 2019

The EMBO Journal

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25 October 2019

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25 October 2019

2424-2435

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25 October 2019

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25 October 2019

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface

1 reference

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Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

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Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160

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24 March 2017

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo

1 reference

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Rapid and efficient site-specific mutagenesis without phenotypic selection

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24 March 2017

Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase

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Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4

1 reference

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24 March 2017

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen

1 reference

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24 March 2017

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin

1 reference

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Signal-dependent membrane protein trafficking in the endocytic pathway

1 reference

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7 April 2017

Role of conserved glycosylation sites in maturation and transport of influenza A virus hemagglutinin.

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27 September 2017

TGN38 is maintained in the trans-Golgi network by a tyrosine-containing motif in the cytoplasmic domain

1 reference

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27 September 2017

Retrieval of transmembrane proteins to the endoplasmic reticulum

1 reference

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27 September 2017

Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=398356

27 September 2017

Oligomerization of a membrane protein correlates with its retention in the Golgi complex

1 reference

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27 September 2017

A cytosolic complex of p62 and rab6 associates with TGN38/41 and is involved in budding of exocytic vesicles from the trans-Golgi network

1 reference

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27 September 2017

cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.

1 reference

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27 September 2017

Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus.

1 reference

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27 September 2017

Eukaryotic membrane traffic: retrieval and retention mechanisms to achieve organelle residence.

1 reference

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27 September 2017

Retrieval of TGN proteins from the cell surface requires endosomal acidification.

1 reference

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27 September 2017

Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2.

1 reference

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27 September 2017

The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=398356

27 September 2017

General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes.

1 reference

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27 September 2017

Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques

1 reference

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27 September 2017

Trafficking of lysosomal enzymes.

1 reference

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27 September 2017

Biosynthetic protein transport and sorting by the endoplasmic reticulum and Golgi

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Dissection of Semliki Forest virus glycoprotein delivery from the trans-Golgi network to the cell surface in permeabilized BHK cells

1 reference

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27 September 2017

The molecular biology of influenza virus pathogenicity

1 reference

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27 September 2017

The trans Golgi network: sorting at the exit site of the Golgi complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=398356

27 September 2017

A specific transmembrane domain of a coronavirus E1 glycoprotein is required for its retention in the Golgi region

1 reference

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27 September 2017

Control of protein exit from the endoplasmic reticulum

1 reference

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27 September 2017

Synthesis of biologically active influenza virus hemagglutinin in insect larvae

1 reference

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A new recombinant DNA strategy for the molecular cloning of rare membrane proteins.

1 reference

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27 September 2017

Sorting within the regulated secretory pathway occurs in the trans-Golgi network

1 reference

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27 September 2017

Sequence of the cDNA encoding rat furin, a possible propeptide-processing endoprotease

1 reference

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27 September 2017

Identification, sequencing and expression of an integral membrane protein of the trans-Golgi network (TGN38)

1 reference

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27 September 2017

Three-dimensional electron microscopy: structure of the Golgi apparatus

1 reference

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Mammalian subtilisins: the long-sought dibasic processing endoproteases

1 reference

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27 September 2017

Immunolocalization of Kex2 protease identifies a putative late Golgi compartment in the yeast Saccharomyces cerevisiae

1 reference

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27 September 2017

Sequences within and adjacent to the transmembrane segment of alpha-2,6-sialyltransferase specify Golgi retention

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The membrane spanning domain of beta-1,4-galactosyltransferase specifies trans Golgi localization

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Multiple targets for brefeldin A.

1 reference

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Mammalian Neural and Endocrine Pro-Protein and Pro-Hormone Convertases Belonging to the Subtilisin Family of Serine Proteinases

1 reference

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Prohormone processing in Xenopus oocytes: characterization of cleavage signals and cleavage enzymes

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27 September 2017

The 17-residue transmembrane domain of beta-galactoside alpha 2,6-sialyltransferase is sufficient for Golgi retention

1 reference

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The new enzymology of precursor processing endoproteases

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1 reference

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Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease

1 reference

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1 reference

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30 May 2018

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30 May 2018

The TGN38 glycoprotein contains two non-overlapping signals that mediate localization to the trans-Golgi network

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30 May 2018

Tail-specific antibodies that block return of 46,000 M(r) mannose 6-phosphate receptor to the trans-Golgi network

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30 May 2018

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30 May 2018

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30 May 2018

Intracellular targeting and structural conservation of a prohormone-processing endoprotease.

1 reference

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30 May 2018

The dynamic nature of the Golgi complex

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30 May 2018

Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells

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30 May 2018

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30 May 2018

Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes

1 reference

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30 May 2018

Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3.

1 reference

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30 May 2018

Perturbation of the morphology of the trans-Golgi network following Brefeldin A treatment: redistribution of a TGN-specific integral membrane protein, TGN38

1 reference

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30 May 2018

The signal for Golgi retention of bovine beta 1,4-galactosyltransferase is in the transmembrane domain

1 reference

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30 May 2018

Hemagglutinin activation of pathogenic avian influenza viruses of serotype H7 requires the protease recognition motif R-X-K/R-R

1 reference

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30 May 2018

Cloning and functional expression of Dfurin2, a subtilisin-like proprotein processing enzyme of Drosophila melanogaster with multiple repeats of a cysteine motif

1 reference

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30 May 2018

In AtT20 and HeLa cells brefeldin A induces the fusion of tubular endosomes and changes their distribution and some of their endocytic properties

1 reference

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30 May 2018

The trans-Golgi network can be dissected structurally and functionally from the cisternae of the Golgi complex by brefeldin A

1 reference

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30 May 2018

The internalization signal in the cytoplasmic tail of lysosomal acid phosphatase consists of the hexapeptide PGYRHV

1 reference

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30 May 2018

Basolateral sorting of LDL receptor in MDCK cells: the cytoplasmic domain contains two tyrosine-dependent targeting determinants

1 reference

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30 May 2018

Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.

1 reference

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19 June 2018

Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediated by the human endoprotease furin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=398356

28 November 2018

Protein sorting by selective retention in the endoplasmic reticulum and Golgi stack

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=398356

28 November 2018

Positional and additive effects of basic amino acids on processing of precursor proteins within the constitutive secretory pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/7781597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SXYQRL sequence in the cytoplasmic domain of TGN38 plays a major role in trans-Golgi network localization

1 reference

https://pubmed.ncbi.nlm.nih.gov/7781597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective processing of the insulin receptor in an endoprotease-deficient Chinese hamster cell strain is corrected by expression of mouse furin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7781597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/7781597

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/J.1460-2075.1995.TB07240.X

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7781597%20AND%20SRC:MED&resulttype=core&format=json

25 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7781597%20AND%20SRC:MED&resulttype=core&format=json

25 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7781597%20AND%20SRC:MED&resulttype=core&format=json

25 October 2019

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