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The hippo signaling pathway in development and cancer
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title
The hippo signaling pathway in development and cancer
(English)
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author name string
Duojia Pan
series ordinal
1
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language of work or name
English
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publication date
19 October 2010
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number of pages
15
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inferred from page(s)
published in
Developmental Cell
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volume
19
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page(s)
491-505
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issue
4
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cites work
The Hippo pathway regulates Wnt/beta-catenin signaling
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Ajuba LIM proteins are negative regulators of the Hippo signaling pathway
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Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus
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Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded
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A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)
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Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
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7 April 2017
Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc
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TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition
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Identification of Fat4 as a candidate tumor suppressor gene in breast cancers
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The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity
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Expression of Yes-associated protein in common solid tumors
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TEAD mediates YAP-dependent gene induction and growth control
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TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
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MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
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7 April 2017
TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
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PubMed Central
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7 April 2017
Tumor suppressor LATS1 is a negative regulator of oncogene YAP
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7 April 2017
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
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PubMed Central
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7 April 2017
The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
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7 April 2017
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein
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Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila
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7 April 2017
Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
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7 April 2017
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
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7 April 2017
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
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7 April 2017
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
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7 April 2017
A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome
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TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
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Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras
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7 April 2017
RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1
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7 April 2017
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin
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7 April 2017
Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)
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7 April 2017
TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm
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PubMed Central
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7 April 2017
Physical interaction with Yes-associated protein enhances p73 transcriptional activity
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7 April 2017
A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis
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7 April 2017
Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12)
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7 April 2017
A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator
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7 April 2017
Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1
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7 April 2017
Identification of Nore1 as a potential Ras effector
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7 April 2017
Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2
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7 April 2017
Structural basis of YAP recognition by TEAD4 in the Hippo pathway
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7 April 2017
Structural insights into the YAP and TEAD complex
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7 April 2017
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
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7 April 2017
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation
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7 April 2017
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass
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7 April 2017
Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
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7 April 2017
Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)
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7 April 2017
A crucial role of WW45 in developing epithelial tissues in the mouse
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7 April 2017
Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival
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PubMed Central
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7 April 2017
SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila
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PubMed Central
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7 April 2017
DNA profiling of primary serous ovarian and fallopian tube carcinomas with array comparative genomic hybridization and multiplex ligation-dependent probe amplification
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7 April 2017
Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1
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7 April 2017
Novel genomic aberrations in testicular germ cell tumors by array-CGH, and associated gene expression changes
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7 April 2017
Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma
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7 April 2017
Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65
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7 April 2017
Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin
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7 April 2017
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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7 April 2017
Human LATS1 is a mitotic exit network kinase
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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7 April 2017
Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers
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7 April 2017
The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members
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PubMed Central
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7 April 2017
A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration)
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PubMed Central
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7 April 2017
TAZ interacts with TTF-1 and regulates expression of surfactant protein-C
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PubMed Central
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7 April 2017
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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7 April 2017
salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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7 April 2017
The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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7 April 2017
Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase
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PubMed Central
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7 April 2017
Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded
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PubMed Central
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7 April 2017
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
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PubMed Central
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7 April 2017
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
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PubMed Central
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7 April 2017
Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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7 April 2017
YAP1 increases organ size and expands undifferentiated progenitor cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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7 April 2017
A Sveinsson's chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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7 April 2017
TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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7 April 2017
Transcriptional activity of Pax3 is co-activated by TAZ
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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7 April 2017
Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ
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7 April 2017
Elucidation of a universal size-control mechanism in Drosophila and mammals
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7 April 2017
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors
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7 April 2017
The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
7 April 2017
hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
7 April 2017
Liver regeneration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
7 April 2017
The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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27 September 2017
Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Modulation of fat:dachsous binding by the cadherin domain kinase four-jointed
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The WW domain protein Kibra acts upstream of Hippo in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Kibra is a regulator of the Salvador/Warts/Hippo signaling network
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Yap is a novel regulator of C2C12 myogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The MST1 and hMOB1 tumor suppressors control human centrosome duplication by regulating NDR kinase phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Hippo pathway-dependent and -independent roles of RASSF6.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Drosophila lowfat, a novel modulator of Fat signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Processing and phosphorylation of the Fat receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The Hippo pathway regulates apical-domain size independently of its growth-control function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The DeMSTification of mammalian Ste20 kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The RASSF proteins in cancer; from epigenetic silencing to functional characterization
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
In vivo analysis of Yorkie phosphorylation sites.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
TEADs mediate nuclear retention of TAZ to promote oncogenic transformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Crumbs proteins in epithelial morphogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Rassf family of tumor suppressor polypeptides.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
YAP regulates neural progenitor cell number via the TEA domain transcription factor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Morphogen control of wing growth through the Fat signaling pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Yes-associated protein (YAP) functions as a tumor suppressor in breast.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
In vivo regulation of Yorkie phosphorylation and localization.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Fat and expanded act in parallel to regulate growth through warts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Clinical significance of the loss of MATS1 mRNA expression in colorectal cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Shedding light on Merlin's wizardry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Hippo signaling in organ size control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Delineation of a Fat tumor suppressor pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The bantam microRNA is a target of the hippo tumor-suppressor pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
From cell structure to transcription: Hippo forges a new path
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Control of cell proliferation and apoptosis by mob as tumor suppressor, mats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Robustness of cellular functions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Mapping of MST1 kinase sites of phosphorylation. Activation and autophosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Intrinsic and extrinsic control of growth in developing organs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
27 September 2017
Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
30 May 2018
Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
30 May 2018
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
30 May 2018
Integrated profiling of basal and luminal breast cancers.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
30 May 2018
The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
30 May 2018
The Drosophila RASSF homolog antagonizes the hippo pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
30 May 2018
Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
30 May 2018
Regulation of gene expression at the beginning of mammalian development and the TEAD family of transcription factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
30 May 2018
Expanded functions in the apical cell domain to regulate the growth rate of imaginal discs.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
30 May 2018
The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
30 May 2018
crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
30 May 2018
Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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28 November 2018
RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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28 November 2018
Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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28 November 2018
Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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28 November 2018
The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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28 November 2018
Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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28 November 2018
Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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28 November 2018
The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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28 November 2018
Nonautonomous planar polarity patterning in Drosophila: dishevelled-independent functions of frizzled.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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28 November 2018
Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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28 November 2018
Developmental compartments and planar polarity in Drosophila.
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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28 November 2018
Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
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28 November 2018
Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124840
retrieved
28 November 2018
Human MOB1 expression in non-small-cell lung cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20951342
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A matter of life and death
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20951342
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.DEVCEL.2010.09.011
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
196254
OpenCitations bibliographic resource ID
196254
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
196254
PMCID
3124840
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
196254
PubMed ID
20951342
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
196254
ResearchGate publication ID
47448650
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