(Q24606438)

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PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells

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PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells (English)

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Antonella Bacchiocchi

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Antonella Bacchiocchi

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10

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Mario Sznol

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Michael Krauthammer

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Michael Krauthammer

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author name string

Ruth Halaban

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Wengeng Zhang

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Elaine Cheng

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Fabio Parisi

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Stephan Ariyan

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James P McCusker

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Yuval Kluger

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publication date

April 2010

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Pigment Cell & Melanoma Research

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23

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2

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190-200

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describes a project that uses

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1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2848976/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

1 reference

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7 April 2017

The Catalogue of Somatic Mutations in Cancer (COSMIC)

1 reference

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7 April 2017

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

1 reference

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7 April 2017

Second nature: biological functions of the Raf-1 "kinase"

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

7 April 2017

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

7 April 2017

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

1 reference

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7 April 2017

Major response to imatinib mesylate in KIT-mutated melanoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

7 April 2017

A dimerization-dependent mechanism drives RAF catalytic activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

7 April 2017

Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

7 April 2017

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

7 April 2017

Regulation and role of Raf-1/B-Raf heterodimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

7 April 2017

The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

7 April 2017

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

1 reference

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7 April 2017

Focal adhesion kinase: in command and control of cell motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

7 April 2017

Response to gefitinib and erlotinib in Non-small cell lung cancer: a restrospective study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

27 September 2017

BRAF signaling and targeted therapies in melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

27 September 2017

Genetic subgrouping of melanoma reveals new opportunities for targeted therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

27 September 2017

Imatinib targeting of KIT-mutant oncoprotein in melanoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

27 September 2017

MAP3Ks as central regulators of cell fate during development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

27 September 2017

BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

27 September 2017

Oncogene addiction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

27 September 2017

Oncogene addiction: setting the stage for molecularly targeted cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

27 September 2017

Somatic activation of KIT in distinct subtypes of melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

27 September 2017

Paradoxical activation of Raf by a novel Raf inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

27 September 2017

Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848976

27 September 2017

Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/20149136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of p90RSK as the probable CREB-Ser133 kinase in human melanocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20149136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of Raf-1 activation in mitosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20149136

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1755-148X.2010.00685.X

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10.1111/J.1755-148X.2010.00683.X

1 reference

Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

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Consolidated OpenCitations Corpus – April 2017

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