(Q24610836)

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Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

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Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas (English)

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cholangiocarcinoma

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hypermethylation

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based on heuristic

inferred from title

18

object named as

G Getz

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author name string

P Wang

1

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Q Dong

2

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C Zhang

3

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P-F Kuan

4

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Y Liu

5

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W R Jeck

6

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J B Andersen

7

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W Jiang

8

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G L Savich

9

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T-X Tan

10

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J T Auman

11

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J M Hoskins

12

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A D Misher

13

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C D Moser

14

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S M Yourstone

15

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J W Kim

16

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K Cibulskis

17

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H V Hunt

19

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S S Thorgeirsson

20

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L R Roberts

21

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D Ye

22

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K-L Guan

23

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Y Xiong

24

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L-X Qin

25

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D Y Chiang

26

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language of work or name

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publication date

20 June 2013

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32

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3091-100

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25

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describes a project that uses

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Europe PubMed Central

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

based on heuristic

inferred from PubMed Central ID database lookup

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

1 reference

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7 April 2017

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

1 reference

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Initial genome sequencing and analysis of multiple myeloma

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

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The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

1 reference

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IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas

1 reference

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IDH1 and IDH2 mutations in gliomas

1 reference

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7 April 2017

An integrated genomic analysis of human glioblastoma multiforme

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7 April 2017

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

1 reference

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7 April 2017

CpG island methylator phenotype in colorectal cancer

1 reference

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Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H

1 reference

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7 April 2017

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

1 reference

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7 April 2017

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

1 reference

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7 April 2017

The epigenomics of cancer

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7 April 2017

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500578

7 April 2017

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

1 reference

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7 April 2017

Epigenetic stem cell signature in cancer

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7 April 2017

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

1 reference

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7 April 2017

Emerging insights into the molecular and cellular basis of glioblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500578

27 September 2017

Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500578

27 September 2017

Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500578

27 September 2017

Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500578

27 September 2017

Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500578

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Genome-scale analysis of aberrant DNA methylation in colorectal cancer

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IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

1 reference

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Breast cancer methylomes establish an epigenomic foundation for metastasis

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27 September 2017

Mutant IDH1 confers an in vivo growth in a melanoma cell line with BRAF mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500578

27 September 2017

DNA methylation of the first exon is tightly linked to transcriptional silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500578

27 September 2017

Enrichment map: a network-based method for gene-set enrichment visualization and interpretation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500578

27 September 2017

An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer

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27 September 2017

Genetics of biliary tract cancers and emerging targeted therapies

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27 September 2017

IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

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27 September 2017

Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias

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27 September 2017

Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500578

27 September 2017

Design and endpoints of clinical trials in hepatocellular carcinoma.

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27 September 2017

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

1 reference

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27 September 2017

Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells

1 reference

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30 May 2018

The biliary tree--a reservoir of multipotent stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.315

21 January 2018

Isocitrate dehydrogenase 1 and 2 mutations in cholangiocarcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500578

28 November 2018

Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.315

31 March 2020

Gastric mucin phenotype defines tumour progression and prognosis of intrahepatic cholangiocarcinoma: gastric foveolar type is associated with aggressive tumour behaviour

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.315

31 March 2020

Identifiers

10.1038/ONC.2012.315

1 reference

Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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Springer Nature article ID

10.1038/onc.2012.315

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