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Trex1 prevents cell-intrinsic initiation of autoimmunity
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title
Trex1 prevents cell-intrinsic initiation of autoimmunity
(English)
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main subject
Three prime repair exonuclease 1
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GOA release 2020-03-11
author
Thierry Heidmann
series ordinal
3
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Joan Ko
object named as
Joan S Ko
series ordinal
2
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Ruslan Medzhitov
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4
object named as
Ruslan Medzhitov
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author name string
Daniel B Stetson
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1
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language of work or name
English
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publication date
22 August 2008
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published in
Cell
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volume
134
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page(s)
587-98
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issue
4
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cites work
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The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death
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Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis
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Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
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Role of endogenous retroviruses in autoimmune diseases
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Identifiers
DOI
10.1016/J.CELL.2008.06.032
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1233587
OpenCitations bibliographic resource ID
1233587
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1233587
PMCID
2626626
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1233587
PubMed ID
18724932
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1233587
ResearchGate publication ID
23191713
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