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Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin
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Europe PubMed Central
PMC publication ID
2662222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
title
Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
2662222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
main subject
cell biology
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author
Ulrich Rass
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
2662222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
Stephen C. West
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
2662222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
author name string
Ivan Ahel
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
2662222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
language of work or name
English
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publication date
3 October 2008
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Europe PubMed Central
PMC publication ID
2662222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
published in
Journal of Biological Chemistry
1 reference
stated in
Europe PubMed Central
PMC publication ID
2662222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
volume
283
1 reference
stated in
Europe PubMed Central
PMC publication ID
2662222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
issue
49
1 reference
stated in
Europe PubMed Central
PMC publication ID
2662222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
page(s)
33994-34001
1 reference
stated in
Europe PubMed Central
PMC publication ID
2662222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
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Actions of aprataxin in multiple DNA repair pathways
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The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates
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Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities
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The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4
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Aprataxin, a novel protein that protects against genotoxic stress
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Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein
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Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases
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XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage
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Structure-based analysis of catalysis and substrate definition in the HIT protein family
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MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family
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Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins
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The role of poly(ADP-ribose) in the DNA damage signaling network
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Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins
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Three-Dimensional Structure of Galactose-1-phosphate Uridylyltransferase from Escherichia coli at 1.8 .ANG. Resolution
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The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin
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7 April 2017
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene
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7 April 2017
The nicotinamide dinucleotide binding motif: a comparison of nucleotide binding proteins
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Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue
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DNA single-strand break repair is impaired in aprataxin-related ataxia.
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A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment
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DNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase. Identification of two functionally distinct DNA binding regions within DNA ligase III.
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28 September 2017
XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro
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28 September 2017
The HIT protein family: a new family of proteins present in prokaryotes, yeast and mammals
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28 September 2017
The novel human gene aprataxin is directly involved in DNA single-strand-break repair.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1074%2FJBC.M807124200
retrieved
21 January 2018
Identifiers
DOI
10.1074/JBC.M807124200
1 reference
stated in
Europe PubMed Central
PMC publication ID
2662222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
PMC publication ID
2662222
1 reference
stated in
Europe PubMed Central
PMC publication ID
2662222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
PubMed publication ID
18836178
1 reference
stated in
Europe PubMed Central
PMC publication ID
2662222
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18836178%20AND%20SRC:MED&resulttype=core&format=json
retrieved
15 January 2020
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