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A complex interplay between Akt, TSC2 and the two mTOR complexes
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scholarly article
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review article
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Europe PubMed Central
title
A complex interplay between Akt, TSC2 and the two mTOR complexes
(English)
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author name string
Jingxiang Huang
series ordinal
1
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Brendan D Manning
series ordinal
2
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language of work or name
English
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publication date
February 2009
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published in
Biochemical Society Transactions
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volume
37
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page(s)
217-22
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issue
Pt 1
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cites work
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The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
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Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
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AKT/PKB signaling: navigating downstream
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Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning
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PubMed Central
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7 April 2017
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
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7 April 2017
Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis
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7 April 2017
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
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Mechanism of activation of protein kinase B by insulin and IGF-1
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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
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mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
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TOR signaling in growth and metabolism
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7 April 2017
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2
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Upstream and downstream of mTOR
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PubMed Central
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7 April 2017
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
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7 April 2017
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
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PubMed Central
reference URL
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7 April 2017
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
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PubMed Central
reference URL
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7 April 2017
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
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7 April 2017
Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026
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7 April 2017
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
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PubMed Central
reference URL
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7 April 2017
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
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PubMed Central
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7 April 2017
The tuberous sclerosis complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026
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7 April 2017
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026
retrieved
7 April 2017
Akt regulates growth by directly phosphorylating Tsc2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026
retrieved
7 April 2017
PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026
retrieved
28 September 2017
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026
retrieved
28 September 2017
FOXO-regulated transcription restricts overgrowth of Tsc mutant organs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026
retrieved
28 September 2017
Restraining PI3K: mTOR signalling goes back to the membrane.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026
retrieved
28 September 2017
Rheb fills a GAP between TSC and TOR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026
retrieved
28 September 2017
The many forks in FOXO's road
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026
retrieved
28 September 2017
S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026
retrieved
30 May 2018
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2778026
retrieved
28 November 2018
Identifiers
DOI
10.1042/BST0370217
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1398037
Fatcat ID
release_6v2qvw3v65h7vjk5wdoq2geh3y
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/6v2qvw3v65h7vjk5wdoq2geh3y
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
OpenCitations bibliographic resource ID
1398037
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1398037
PMCID
2778026
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1398037
PubMed ID
19143635
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1398037
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