Wikidata

(Q254943)

English

retinoic acid receptor alpha

mammalian protein found in Homo sapiens

  • retinoic acid nuclear receptor alpha variant 2
  • retinoic acid receptor, alpha polypeptide
  • nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form
  • RAR-alpha
  • nuclear receptor subfamily 1 group B member 1
  • retinoic acid nuclear receptor alpha variant 1
  • RARA
In more languages

Statements

molecular function
protein binding
determination method
IPI
30 references
retrieved
8 April 2019
stated in
Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation
GOA
curator
UniProt
UniProt protein ID
P10276
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Small ubiquitin-like modifier-2 modification of retinoic acid receptor-alpha regulates its subcellular localization and transcriptional activity
GOA
curator
UniProt
UniProt protein ID
P10276
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription
GOA
curator
UniProt
UniProt protein ID
P10276
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer
GOA
curator
UniProt
UniProt protein ID
P10276
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
GOA
curator
UniProt
UniProt protein ID
P10276
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Small ubiquitin-related modifier-1 modification regulates all-trans-retinoic acid-induced differentiation via stabilization of retinoic acid receptor α
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
A retinoic acid receptor RARα pool present in membrane lipid rafts forms complexes with G protein αQ to activate p38MAPK
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Enhancer activation requires trans-recruitment of a mega transcription factor complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
retrieved
8 April 2019
stated in
The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IPI
cell component
nucleus
determination method
IDA
IEA
7 references
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P10276
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10276&geneProductId=UniProtKB:P10276
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10276&geneProductId=UniProtKB:P10276
determination method
IEA
retrieved
5 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10276&geneProductId=UniProtKB:P10276
determination method
IEA
retrieved
5 June 2018
stated in
Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation
GOA
curator
UniProt
UniProt protein ID
P10276
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10276&geneProductId=UniProtKB:P10276
determination method
IDA
retrieved
5 June 2018
stated in
Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer
GOA
curator
UniProt
UniProt protein ID
P10276
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10276&geneProductId=UniProtKB:P10276
determination method
IDA
retrieved
5 June 2018
stated in
Retinoic acid regulates the human methionine sulfoxide reductase A (MSRA) gene via two distinct promoters
GOA
curator
UniProt
UniProt protein ID
P10276
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10276&geneProductId=UniProtKB:P10276
determination method
IDA
retrieved
5 June 2018
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10276&geneProductId=UniProtKB:P10276
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P10276
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IEA
retrieved
8 April 2019
stated in
Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation
GOA
curator
UniProt
UniProt protein ID
P10276
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IDA
retrieved
8 April 2019
stated in
Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer
GOA
curator
UniProt
UniProt protein ID
P10276
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IDA
retrieved
8 April 2019
stated in
Retinoic acid regulates the human methionine sulfoxide reductase A (MSRA) gene via two distinct promoters
GOA
curator
UniProt
UniProt protein ID
P10276
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IDA
retrieved
8 April 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10276
determination method
IBA
biological process