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Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation
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PubMed
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Europe PubMed Central
title
Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation
(English)
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stated in
PubMed
main subject
apoptotic process
0 references
inflammation
0 references
author
Pascal Meier
object named as
P. Meier
series ordinal
2
0 references
John Silke
object named as
J. Silke
series ordinal
1
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language of work or name
English
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stated in
PubMed
publication date
1 February 2013
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PubMed
published in
Cold Spring Harbor Perspectives in Biology
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Crossref
volume
5
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stated in
PubMed
issue
2
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PubMed
cites work
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
1 reference
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PubMed Central
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SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
1 reference
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PubMed Central
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SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
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PubMed Central
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7 April 2017
Linear ubiquitination prevents inflammation and regulates immune signalling
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PubMed Central
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7 April 2017
Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity
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PubMed Central
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7 April 2017
IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
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7 April 2017
Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
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7 April 2017
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
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7 April 2017
c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation
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7 April 2017
Final stages of cytokinesis and midbody ring formation are controlled by BRUCE
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7 April 2017
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation
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PubMed Central
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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
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7 April 2017
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family
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7 April 2017
A ubiquitin ligase complex assembles linear polyubiquitin chains
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PubMed Central
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7 April 2017
Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases
1 reference
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PubMed Central
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7 April 2017
Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase
1 reference
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PubMed Central
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7 April 2017
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
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7 April 2017
NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100
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PubMed Central
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7 April 2017
Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
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7 April 2017
X-linked IAP is a direct inhibitor of cell-death proteases
1 reference
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PubMed Central
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7 April 2017
An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs
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PubMed Central
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7 April 2017
Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination
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PubMed Central
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7 April 2017
CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration
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PubMed Central
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7 April 2017
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
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PubMed Central
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7 April 2017
Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles
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7 April 2017
Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment
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PubMed Central
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7 April 2017
XIAP Induces NF-κB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization
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7 April 2017
Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination
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7 April 2017
Structural basis of IAP recognition by Smac/DIABLO
1 reference
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PubMed Central
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7 April 2017
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex
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PubMed Central
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7 April 2017
The ubiquitin code
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PubMed Central
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7 April 2017
TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
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PubMed Central
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7 April 2017
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function
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7 April 2017
Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses
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7 April 2017
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
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7 April 2017
N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway
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7 April 2017
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
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7 April 2017
Molecular mechanisms of necroptosis: an ordered cellular explosion
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7 April 2017
The host defense of Drosophila melanogaster
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7 April 2017
NF-kappaB: linking inflammation and immunity to cancer development and progression
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7 April 2017
Molecular mechanisms of caspase regulation during apoptosis
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7 April 2017
IAP proteins: blocking the road to death's door
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7 April 2017
Ubiquitination in signaling to and activation of IKK.
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28 September 2017
No one can whistle a symphony alone - how different ubiquitin linkages cooperate to orchestrate NF-κB activity
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28 September 2017
IAPs limit activation of RIP kinases by TNF receptor 1 during development
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28 September 2017
The regulation of TNF signalling: what a tangled web we weave
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28 September 2017
Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER.
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28 September 2017
The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs
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28 September 2017
Functional complementation between FADD and RIP1 in embryos and lymphocytes
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28 September 2017
In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8
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28 September 2017
FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity
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PubMed Central
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28 September 2017
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling
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PubMed Central
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28 September 2017
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
1 reference
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PubMed Central
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28 September 2017
The emerging complexity of protein ubiquitination
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28 September 2017
XIAP mediates NOD signaling via interaction with RIP2
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PubMed Central
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28 September 2017
Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes
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28 September 2017
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.
1 reference
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PubMed Central
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28 September 2017
Ubiquitylation in innate and adaptive immunity.
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PubMed Central
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28 September 2017
Death receptor signal transducers: nodes of coordination in immune signaling networks
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28 September 2017
Inactivation of effector caspases through nondegradative polyubiquitylation
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28 September 2017
Regulation of the Drosophila apoptosome through feedback inhibition
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28 September 2017
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.
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28 September 2017
IAP-targeted therapies for cancer
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28 September 2017
Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.
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28 September 2017
Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation
1 reference
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PubMed Central
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28 September 2017
The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors
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28 September 2017
IAPs: what's in a name?
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PubMed Central
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28 September 2017
DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells
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28 September 2017
The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections
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28 September 2017
The antiapoptotic activity of insect IAPs requires activation by an evolutionarily conserved mechanism
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28 September 2017
Ubiquitin and ubiquitin-like proteins in cancer pathogenesis
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28 September 2017
The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection
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PubMed Central
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28 September 2017
An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila.
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28 September 2017
Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway
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28 September 2017
Regulators of the Toll and Imd pathways in the Drosophila innate immune response
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28 September 2017
IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 September 2017
The role of ARK in stress-induced apoptosis in Drosophila cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 September 2017
The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 September 2017
A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 September 2017
The Drosophila caspase DRONC is regulated by DIAP1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 September 2017
Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 September 2017
Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 September 2017
Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 September 2017
Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 September 2017
The Drosophila inhibitor of apoptosis D-IAP1 suppresses cell death induced by the caspase drICE.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 September 2017
An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 September 2017
Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
31 May 2018
Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
31 May 2018
RIP1 comes back to life as a cell death regulator in TNFR1 signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
31 May 2018
Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
31 May 2018
IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
31 May 2018
The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
31 May 2018
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Engineered hybrid dimers: tracking the activation pathway of caspase-7.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
The role of ubiquitination in Drosophila innate immunity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Immune Activation of NF-κB and JNK Requires Drosophila TAK1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Caspase Activity and a Specific Cytochrome C Are Required for Sperm Differentiation in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Cutting edge: the toll pathway is required for resistance to gram-positive bacterial infections in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Role of Drosophila IKK gamma in a toll-independent antibacterial immune response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552501
retrieved
28 November 2018
The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23378585
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23378585
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ubiquitylation in apoptosis: DIAP1's (N-)en(d)igma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23378585
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1101/CSHPERSPECT.A008730
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2514420
OpenCitations bibliographic resource ID
2514420
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2514420
PMC publication ID
3552501
1 reference
stated in
PubMed
PubMed publication ID
23378585
1 reference
stated in
PubMed
ResearchGate publication ID
235398763
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