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RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis
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title
RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis
(English)
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stated in
PubMed
author name string
Stanley Lipkowitz
series ordinal
1
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Crossref
Allan M. Weissman
series ordinal
2
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Crossref
language of work or name
English
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stated in
PubMed
publication date
24 August 2011
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stated in
PubMed
published in
Nature Reviews Cancer
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PubMed
volume
11
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stated in
PubMed
page(s)
629-43
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stated in
PubMed
issue
9
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PubMed
cites work
Hallmarks of Cancer: The Next Generation
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7 April 2017
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair
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PubMed Central
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7 April 2017
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents
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PubMed Central
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PubMed Central
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PubMed Central
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Control of cell growth by the SCF and APC/C ubiquitin ligases
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PubMed Central
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1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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7 April 2017
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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1 reference
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PubMed Central
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1 reference
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PubMed Central
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PubMed Central
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Role of the F-box protein Skp2 in lymphomagenesis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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7 April 2017
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1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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Identification of a cryptic nucleolar-localization signal in MDM2
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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7 April 2017
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1
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PubMed Central
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PubMed Central
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7 April 2017
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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PubMed Central
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7 April 2017
Mdm2 promotes the rapid degradation of p53
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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7 April 2017
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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PubMed Central
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7 April 2017
Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C
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PubMed Central
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7 April 2017
Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
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PubMed Central
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7 April 2017
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
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PubMed Central
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7 April 2017
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7 April 2017
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7 April 2017
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Wnt/beta-catenin signaling in development and disease
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7 April 2017
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
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7 April 2017
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
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PubMed Central
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7 April 2017
Regulation of p53 stability by Mdm2
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PubMed Central
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7 April 2017
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PubMed Central
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7 April 2017
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain
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PubMed Central
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7 April 2017
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
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7 April 2017
ErbB2 degradation mediated by the co-chaperone protein CHIP
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PubMed Central
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7 April 2017
Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein
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7 April 2017
Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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7 April 2017
Oncogenic kinase signalling
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PubMed Central
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7 April 2017
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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7 April 2017
Role of direct interaction in BRCA1 inhibition of estrogen receptor activity
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PubMed Central
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7 April 2017
The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7
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PubMed Central
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7 April 2017
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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7 April 2017
Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7
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PubMed Central
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7 April 2017
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
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7 April 2017
MDM2 interacts with MDMX through their RING finger domains
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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7 April 2017
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis
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7 April 2017
Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells
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7 April 2017
The Cbl interactome and its functions
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7 April 2017
E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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7 April 2017
Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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7 April 2017
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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7 April 2017
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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7 April 2017
Association of BRCA1 with Rad51 in mitotic and meiotic cells
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7 April 2017
Amplification of a gene encoding a p53-associated protein in human sarcomas
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PubMed Central
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7 April 2017
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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7 April 2017
Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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7 April 2017
Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase
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7 April 2017
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation
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7 April 2017
Blinded by the Light: The Growing Complexity of p53
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7 April 2017
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial
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PubMed Central
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7 April 2017
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
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7 April 2017
The anaphase promoting complex/cyclosome: a machine designed to destroy
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7 April 2017
Ubiquitin ligases: cell-cycle control and cancer
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7 April 2017
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability
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7 April 2017
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
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PubMed Central
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7 April 2017
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
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PubMed Central
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7 April 2017
Nucleolar Arf sequesters Mdm2 and activates p53
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PubMed Central
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7 April 2017
Brca1 controls homology-directed DNA repair
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PubMed Central
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7 April 2017
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
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7 April 2017
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
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7 April 2017
Identification of the von Hippel-Lindau disease tumor suppressor gene
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7 April 2017
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
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7 April 2017
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
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7 April 2017
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial
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25 May 2017
COP1 is a tumour suppressor that causes degradation of ETS transcription factors
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28 September 2017
MDM2 antagonists boost antitumor effect of androgen withdrawal: implications for therapy of prostate cancer
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28 September 2017
Effect of MDM2 and vascular endothelial growth factor inhibition on tumor angiogenesis and metastasis in neuroblastoma
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28 September 2017
Proteasome inhibitors in cancer therapy
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28 September 2017
Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice.
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28 September 2017
BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions
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28 September 2017
Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells
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28 September 2017
The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme
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PubMed Central
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28 September 2017
Oncogenic activation of NF-kappaB.
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28 September 2017
Cbl and human myeloid neoplasms: the Cbl oncogene comes of age.
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28 September 2017
The genetic basis of kidney cancer: a metabolic disease
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28 September 2017
The p53 orchestra: Mdm2 and Mdmx set the tone
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases
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28 September 2017
BRCA1 and its toolbox for the maintenance of genome integrity
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28 September 2017
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.
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PubMed Central
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28 September 2017
Siah proteins: novel drug targets in the Ras and hypoxia pathways
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28 September 2017
BRCA1 regulates acetylation and ubiquitination of estrogen receptor-alpha
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28 September 2017
Signaling to p53: ribosomal proteins find their way.
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28 September 2017
The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
The multiple levels of regulation by p53 ubiquitination
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28 September 2017
Novel roles of hakai in cell proliferation and oncogenesis
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28 September 2017
Mdm2-mediated ubiquitylation: p53 and beyond.
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28 September 2017
Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.
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28 September 2017
Mechanism of BRCA1-mediated inhibition of progesterone receptor transcriptional activity
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28 September 2017
CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Ubiquitin in trafficking: the network at work
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28 September 2017
Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.
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28 September 2017
IAPs as a target for anticancer therapy.
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28 September 2017
The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation
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28 September 2017
CUL7 is a novel antiapoptotic oncogene
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28 September 2017
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
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28 September 2017
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERalpha-negative and ERalpha-positive mammary preneoplasia and cancer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
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28 September 2017
Therapeutic targets in the ARF tumor suppressor pathway.
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28 September 2017
The ubiquitin ligase SCF(betaTrCP) regulates the degradation of the growth hormone receptor
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Estrogen receptor alpha is a putative substrate for the BRCA1 ubiquitin ligase
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Ablation of Cbl-b provides protection against transplanted and spontaneous tumors
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Regulating the regulator: negative regulation of Cbl ubiquitin ligases
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28 September 2017
Tumor suppression and normal aging in mice with constitutively high p53 activity
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer.
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28 September 2017
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches.
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28 September 2017
Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases
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28 September 2017
Parc: a cytoplasmic anchor for p53.
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28 September 2017
Deregulated degradation of the cdk inhibitor p27 and malignant transformation.
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28 September 2017
Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu
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28 September 2017
Role of FLT3 in leukemia
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28 September 2017
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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28 September 2017
Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 September 2017
Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 September 2017
Skp2 is oncogenic and overexpressed in human cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 September 2017
BRCA1 and BRCA2 and the genetics of breast and ovarian cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 September 2017
Cbl-b regulates the CD28 dependence of T-cell activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 September 2017
The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 September 2017
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 September 2017
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 September 2017
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
31 May 2018
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
31 May 2018
BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
31 May 2018
Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
31 May 2018
Mutations of the VHL tumour suppressor gene in renal carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
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31 May 2018
Tumour suppression by the human von Hippel-Lindau gene product
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
31 May 2018
SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
BARD1 homozygous deletion, a possible alternative to BRCA1 mutation in basal breast cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53wild-type CLL with a poor cytotoxic response to Nutlin-3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
Mutation of the RAD51C gene in a Fanconi anemia-like disorder
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
Genomic stability and tumour suppression by the APC/C cofactor Cdh1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
Flt3-dependent transformation by inactivating c-Cbl mutations in AML
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
PARC and CUL7 form atypical cullin RING ligase complexes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542975
retrieved
28 November 2018
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1038%2FNRC3120
retrieved
31 March 2020
BRCA1 ubiquitylation of CtIP: Just the tIP of the iceberg?
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1038%2FNRC3120
retrieved
31 March 2020
cbl-b inhibits EGF-receptor-induced apoptosis by enhancing ubiquitination and degradation of activated receptors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRC3120
retrieved
31 March 2020
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNRC3120
retrieved
31 March 2020
Cancer predisposing missense and protein truncating BARD1 mutations in non-BRCA1 or BRCA2 breast cancer families
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1038%2FNRC3120
retrieved
31 March 2020
Cancer predisposing BARD1 mutations in breast-ovarian cancer families
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21863050
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/NRC3120
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1116352
Dimensions Publication ID
1016268056
0 references
OpenCitations bibliographic resource ID
1116352
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1116352
PMCID
3542975
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1116352
PubMed ID
21863050
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1116352
ResearchGate publication ID
51591655
0 references
Springer Nature article ID
10.1038/nrc3120
0 references
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