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Molecular mechanisms of epithelial-mesenchymal transition
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PubMed
review article
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Europe PubMed Central
title
Molecular mechanisms of epithelial-mesenchymal transition
(English)
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author name string
Samy Lamouille
series ordinal
1
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stated in
Crossref
Jian Xu
series ordinal
2
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stated in
Crossref
Rik Derynck
series ordinal
3
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Crossref
language of work or name
English
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PubMed
publication date
March 2014
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stated in
PubMed
published in
Nature Reviews Molecular Cell Biology
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PubMed
volume
15
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stated in
PubMed
page(s)
178-96
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PubMed
issue
3
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PubMed
cites work
Epithelial-mesenchymal transitions: insights from development
1 reference
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PubMed Central
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21 March 2017
Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease
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21 March 2017
SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities
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PubMed Central
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21 March 2017
Regulation of endothelial cell plasticity by TGF-β
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Hallmarks of Cancer: The Next Generation
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21 March 2017
Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.
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PubMed Central
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21 March 2017
Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition
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PubMed Central
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Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis
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PubMed Central
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ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1
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PubMed Central
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miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
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PubMed Central
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Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer
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PubMed Central
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21 March 2017
The basics of epithelial-mesenchymal transition
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PubMed Central
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21 March 2017
Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
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21 March 2017
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21 March 2017
Small C-terminal domain phosphatase enhances snail activity through dephosphorylation
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PubMed Central
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21 March 2017
HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
1 reference
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PubMed Central
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MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
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PubMed Central
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21 March 2017
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
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21 March 2017
Slug is a direct Notch target required for initiation of cardiac cushion cellularization
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PubMed Central
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21 March 2017
The epithelial-mesenchymal transition generates cells with properties of stem cells
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PubMed Central
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21 March 2017
Direct regulation of TWIST by HIF-1alpha promotes metastasis
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PubMed Central
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Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling
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Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
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21 March 2017
Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
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PubMed Central
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A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells
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21 March 2017
The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin
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21 March 2017
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
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21 March 2017
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
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PubMed Central
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21 March 2017
Hypoxia Attenuates the Expression of E-Cadherin via Up-Regulation of SNAIL in Ovarian Carcinoma Cells
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21 March 2017
Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins
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21 March 2017
Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway
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PubMed Central
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21 March 2017
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
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21 March 2017
The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition
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PubMed Central
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21 March 2017
A Poised Chromatin Platform for TGF-β Access to Master Regulators
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21 March 2017
A Smad action turnover switch operated by WW domain readers of a phosphoserine code
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21 March 2017
Epithelial-mesenchymal transitions in development and disease
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21 March 2017
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
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21 March 2017
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
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21 March 2017
Development of heart valves requires Gata4 expression in endothelial-derived cells
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21 March 2017
Smad-dependent and Smad-independent pathways in TGF-beta family signalling
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21 March 2017
TGF-beta signal transduction and mesangial cell fibrogenesis
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21 March 2017
The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation
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21 March 2017
TGF-beta signaling by Smad proteins
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21 March 2017
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21 March 2017
Requirement for Wnt3 in vertebrate axis formation
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21 March 2017
Association of the HGF/SF receptor, c-met, with the cell-surface adhesion molecule, E-cadherin, and catenins in human tumor cells
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21 March 2017
ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling
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21 March 2017
TGFβ signalling in context
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21 March 2017
TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition
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21 March 2017
GATA switches as developmental drivers
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21 March 2017
TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA
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21 March 2017
Opposing LSD1 complexes function in developmental gene activation and repression programmes
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21 March 2017
Molecular definition of breast tumor heterogeneity
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21 March 2017
DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation
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21 March 2017
Integrin-mediated activation of latent transforming growth factor beta
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21 March 2017
Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo
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21 March 2017
The transcriptional repressor Snail promotes mammary tumor recurrence
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21 March 2017
Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression
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21 March 2017
Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions
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21 March 2017
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28 November 2018
Junctional recruitment of mammalian Scribble relies on E-cadherin engagement
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21 March 2017
Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos
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21 March 2017
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21 March 2017
LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta
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21 March 2017
Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm
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21 March 2017
TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A
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21 March 2017
Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization
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21 March 2017
A proximal activator of transcription in epithelial-mesenchymal transition
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21 March 2017
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
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21 March 2017
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
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21 March 2017
Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo
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21 March 2017
Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium
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7 April 2017
Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation
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7 April 2017
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
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7 April 2017
Complex networks orchestrate epithelial-mesenchymal transitions
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7 April 2017
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
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7 April 2017
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7 April 2017
A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
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7 April 2017
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7 April 2017
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
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7 April 2017
Specificity and versatility in tgf-beta signaling through Smads
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7 April 2017
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7 April 2017
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
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7 April 2017
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9 May 2017
Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
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28 September 2017
Notch Signaling Pathway in Pancreatic Cancer Progression
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28 September 2017
Notch signaling at a glance
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28 September 2017
The mechanisms of Hedgehog signalling and its roles in development and disease
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28 September 2017
p120 catenin: an essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression.
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28 September 2017
The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion
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28 September 2017
Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs
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28 September 2017
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28 September 2017
FOXOs: signalling integrators for homeostasis maintenance
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28 September 2017
Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis.
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28 September 2017
Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1.
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28 September 2017
TGF-β signaling and epithelial-mesenchymal transition in cancer progression
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28 September 2017
Early events in cell adhesion and polarity during epithelial-mesenchymal transition.
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28 September 2017
The complex world of WNT receptor signalling
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28 September 2017
Cadherin junctions and their cytoskeleton(s).
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28 September 2017
Epithelial mesenchymal transition and pancreatic tumor initiating CD44+/EpCAM+ cells are inhibited by γ-secretase inhibitor IX.
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28 September 2017
The mesenchymal-to-epithelial transition in somatic cell reprogramming
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28 September 2017
Breaking away: matrix remodeling from the leading edge
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28 September 2017
Cadherins in collective cell migration of mesenchymal cells
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28 September 2017
The role of endothelial-mesenchymal transition in heterotopic ossification
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28 September 2017
Zyxin is a transforming growth factor-β (TGF-β)/Smad3 target gene that regulates lung cancer cell motility via integrin α5β1.
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28 September 2017
TGFβ and BMP signaling in cardiac cushion formation: lessons from mice and chicken
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28 September 2017
Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer.
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28 September 2017
Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links
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28 September 2017
Endothelial-mesenchymal transition and its contribution to the emergence of stem cell phenotype
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28 September 2017
Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer
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28 September 2017
A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition
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28 September 2017
G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer
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28 September 2017
miRNA-29b suppresses prostate cancer metastasis by regulating epithelial-mesenchymal transition signaling
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28 September 2017
TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion
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28 September 2017
Slug and Sox9 cooperatively determine the mammary stem cell state
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28 September 2017
MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms
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28 September 2017
Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases
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28 September 2017
The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer.
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28 September 2017
miR-30 inhibits TGF-β1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1.
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28 September 2017
MiR-365 regulates lung cancer and developmental gene thyroid transcription factor 1
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28 September 2017
Activation of Notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells
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28 September 2017
Specific GATA factors act as conserved inducers of an endodermal-EMT.
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28 September 2017
miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
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28 September 2017
PTTG induces EMT through integrin αVβ3-focal adhesion kinase signaling in lung cancer cells
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28 September 2017
Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression.
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28 September 2017
IL-6 promotes head and neck tumor metastasis by inducing epithelial-mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway
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28 September 2017
β-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition
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28 September 2017
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation.
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28 September 2017
BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study
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28 September 2017
Epithelial-Mesenchymal Transition in tumor microenvironment
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28 September 2017
Inverse association between miR-194 expression and tumor invasion in gastric cancer
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28 September 2017
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
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28 September 2017
Life at the leading edge
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28 September 2017
EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin.
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28 September 2017
The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2.
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28 September 2017
IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells
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28 September 2017
Transforming growth factor-β2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling.
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28 September 2017
p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2.
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28 September 2017
Phosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1 protein and promotes breast cancer cell invasiveness
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28 September 2017
Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells
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28 September 2017
Scar wars: mapping the fate of epithelial-mesenchymal-myofibroblast transition
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28 September 2017
mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways
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28 September 2017
CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression
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28 September 2017
FOXQ1 regulates epithelial-mesenchymal transition in human cancers
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28 September 2017
Small RNA-mediated regulation of iPS cell generation.
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28 September 2017
Epithelial-to-mesenchymal transformation alters electrical conductivity of human epicardial cells
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28 September 2017
Signalling to cancer cell invasion through PAK family kinases
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28 September 2017
Conversion of vascular endothelial cells into multipotent stem-like cells
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28 September 2017
Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition
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28 September 2017
miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice
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28 September 2017
TGF-{beta}-induced MiR-491-5p expression promotes Par-3 degradation in rat proximal tubular epithelial cells
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28 September 2017
Protein kinase D1 suppresses epithelial-to-mesenchymal transition through phosphorylation of snail
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28 September 2017
Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition
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28 September 2017
Transforming growth factor-β-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression
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28 September 2017
An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition
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28 September 2017
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming
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28 September 2017
miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers
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28 September 2017
Cell polarity in eggs and epithelia: parallels and diversity
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28 September 2017
Cell polarity in motion: redefining mammary tissue organization through EMT and cell polarity transitions.
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28 September 2017
Mechanisms of motility in metastasizing cells
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28 September 2017
TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI
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28 September 2017
Nuclear Janus-activated kinase 2/nuclear factor 1-C2 suppresses tumorigenesis and epithelial-to-mesenchymal transition by repressing Forkhead box F1.
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28 September 2017
Fate-determining mechanisms in epithelial-myofibroblast transition: major inhibitory role for Smad3
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28 September 2017
Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition
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28 September 2017
The RhoA activator GEF-H1/Lfc is a transforming growth factor-beta target gene and effector that regulates alpha-smooth muscle actin expression and cell migration
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28 September 2017
Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity
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28 September 2017
Tgfbeta signal inhibition cooperates in the induction of iPSCs and replaces Sox2 and cMyc
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28 September 2017
SOX-partner code for cell specification: Regulatory target selection and underlying molecular mechanisms
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28 September 2017
RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells
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28 September 2017
New regulatory mechanisms of TGF-beta receptor function
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28 September 2017
Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways.
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28 September 2017
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition
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28 September 2017
Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells.
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28 September 2017
Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition
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28 September 2017
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease.
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28 September 2017
p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug
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28 September 2017
HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells
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28 September 2017
Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts
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28 September 2017
EMT, the cytoskeleton, and cancer cell invasion
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28 September 2017
Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion
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28 September 2017
Contact inhibition of locomotion in vivo controls neural crest directional migration
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28 September 2017
Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2.
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28 September 2017
Transcriptional regulation of cell polarity in EMT and cancer
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28 September 2017
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells
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28 September 2017
Signaling mechanisms of neurite outgrowth induced by the cell adhesion molecules NCAM and N-cadherin
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28 September 2017
NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin
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28 September 2017
ERK5/MAPK is activated by TGFbeta in hepatocytes and required for the GSK-3beta-mediated Snail protein stabilization.
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PubMed Central
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28 September 2017
Back and forth between cell fate specification and movement during vertebrate gastrulation
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28 September 2017
Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
A gene regulatory network orchestrates neural crest formation
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28 September 2017
Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
Notch signaling mediates hypoxia-induced tumor cell migration and invasion
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease
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28 September 2017
The Müllerian duct: recent insights into its development and regression.
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28 September 2017
Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells
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28 September 2017
Cadherin switching
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28 September 2017
Modulation of several waves of gene expression during FGF-1 induced epithelial-mesenchymal transition of carcinoma cells
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28 September 2017
Snail and Sonic Hedgehog activation in neuroendocrine tumors of the ileum
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression
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28 September 2017
Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
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28 September 2017
TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease
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28 September 2017
Multiple transforming growth factor-beta isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart
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28 September 2017
Mesenchymal to epithelial transition in development and disease.
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28 September 2017
Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro
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28 September 2017
TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex
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28 September 2017
Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT?
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
JNK mediates TGF-beta1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
Immunoediting of cancers may lead to epithelial to mesenchymal transition.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition.
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28 September 2017
Collagen type I induces disruption of E-cadherin-mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cells
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells
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28 September 2017
Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments.
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28 September 2017
Non-Smad TGF-beta signals
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28 September 2017
Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor
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28 September 2017
Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin
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28 September 2017
The Snail genes as inducers of cell movement and survival: implications in development and cancer.
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28 September 2017
Sclerotome development and morphogenesis: when experimental embryology meets genetics.
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28 September 2017
TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
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28 September 2017
Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition
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28 September 2017
Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro
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28 September 2017
A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition
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28 September 2017
Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV-Cripto-1 transgenic mice
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28 September 2017
Transforming growth factor beta (TGFbeta) signalling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT).
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28 September 2017
Notch and epithelial-mesenchyme transition in development and tumor progression: another turn of the screw.
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28 September 2017
Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo
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28 September 2017
Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
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28 September 2017
Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
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28 September 2017
Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex
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28 September 2017
Mechanical induction of Twist in the Drosophila foregut/stomodeal primordium
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28 September 2017
Hierarchical model of gene regulation by transforming growth factor beta
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
Regulation of leading edge microtubule and actin dynamics downstream of Rac1
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28 September 2017
A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
Roles of TGF-beta in hepatic fibrosis
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28 September 2017
Regulation of Rho GTPases by p120-catenin
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PubMed Central
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28 September 2017
Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta
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28 September 2017
TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
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28 September 2017
Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion.
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28 September 2017
Alpha 2 beta 1 integrin is required for the collagen and FGF-1 induced cell dispersion in a rat bladder carcinoma cell line.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 September 2017
Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition
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31 May 2018
Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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31 May 2018
Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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31 May 2018
Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta
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31 May 2018
Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail
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31 May 2018
Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation
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31 May 2018
Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.
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31 May 2018
Diminished matrix metalloproteinase 2 (MMP-2) in ectomesenchyme-derived tissues of the Patch mutant mouse: regulation of MMP-2 by PDGF and effects on mesenchymal cell migration.
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31 May 2018
An epithelial scatter factor released by embryo fibroblasts.
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31 May 2018
Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition.
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28 November 2018
Mouse snail is a target gene for HIF.
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28 November 2018
Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells.
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28 November 2018
Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated Fibroblasts
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28 November 2018
Insulin-like growth factor-I receptor, E-cadherin and alpha v integrin form a dynamic complex under the control of alpha-catenin.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4240281
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28 November 2018
Activation of FOXO3a by the green tea polyphenol epigallocatechin-3-gallate induces estrogen receptor alpha expression reversing invasive phenotype of breast cancer cells.
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28 November 2018
Epithelial-mesenchymal transition process in human embryonic stem cells cultured in feeder-free conditions.
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28 November 2018
Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development.
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28 November 2018
Tumor cell invasiveness correlates with changes in integrin expression and localization
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28 November 2018
Bone Morphogenic Protein-7 Induces Mesenchymal to Epithelial Transition in Adult Renal Fibroblasts and Facilitates Regeneration of Injured Kidney
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28 November 2018
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.
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28 November 2018
Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.
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28 November 2018
Transforming growth factor-beta and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes.
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28 November 2018
Ectodermal Wnt function as a neural crest inducer.
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28 November 2018
FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak
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28 November 2018
Slug is an essential target of TGFbeta2 signaling in the developing chicken heart.
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28 November 2018
Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front.
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28 November 2018
Epithelial-mesenchymal interactions in pulmonary fibrosis
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31 March 2020
TGF beta-mediated RhoA expression is necessary for epithelial-mesenchymal transition in the embryonic chick heart
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31 March 2020
Epithelial-mesenchymal transition events during human embryonic stem cell differentiation
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31 March 2020
Identifiers
DOI
10.1038/NRM3758
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
132226
Dimensions Publication ID
1000491787
0 references
OpenCitations bibliographic resource ID
132226
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
132226
PMCID
4240281
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
132226
PubMed ID
24556840
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
132226
Springer Nature article ID
10.1038/nrm3758
0 references
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