(Q27021146)

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Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology

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Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology (English)

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blood–brain barrier

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based on heuristic

inferred from title

4

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26106291%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Tina Skjørringe

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26106291%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Annette Burkhart

2

2 references

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26106291%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Kasper Bendix Johnsen

3

2 references

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26106291%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

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2015

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Frontiers in Molecular Neuroscience

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13 June 2020

8

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13 June 2020

19

2 references

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26106291%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin

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21 March 2017

Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1)

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21 March 2017

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

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21 March 2017

Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload

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21 March 2017

A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway

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21 March 2017

DMT1, a physiologically relevant apical Cu1+ transporter of intestinal cells

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21 March 2017

Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function

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21 March 2017

Junctions between intimately apposed cell membranes in the vertebrate brain

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21 March 2017

Astrocyte-endothelial interactions at the blood-brain barrier

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21 March 2017

Rapid regulation of divalent metal transporter (DMT1) protein but not mRNA expression by non-haem iron in human intestinal Caco-2 cells

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21 March 2017

Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target

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21 March 2017

Two to tango: regulation of Mammalian iron metabolism

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21 March 2017

Brain iron metabolism

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21 March 2017

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7 April 2017

Age-dependent and iron-independent expression of two mRNA isoforms of divalent metal transporter 1 in rat brain

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21 March 2017

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

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21 March 2017

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

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Identification of an intestinal heme transporter

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21 March 2017

Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice

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21 March 2017

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

1 reference

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21 March 2017

Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6

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21 March 2017

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes

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21 March 2017

Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons

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28 September 2017

Ndfip1 attenuated 6-OHDA-induced iron accumulation via regulating the degradation of DMT1.

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28 September 2017

A novel model for brain iron uptake: introducing the concept of regulation

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28 September 2017

Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor inhibit ferrous iron influx via divalent metal transporter 1 and iron regulatory protein 1 regulation in ventral mesencephalic neurons

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28 September 2017

The role of iron in brain ageing and neurodegenerative disorders.

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28 September 2017

Blood-brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody

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28 September 2017

Placental fatty acid transport in maternal obesity

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28 September 2017

The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body

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28 September 2017

Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels

1 reference

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28 September 2017

Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle

1 reference

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28 September 2017

Brain angiotensin regulates iron homeostasis in dopaminergic neurons and microglial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Iron metabolism in the CNS: implications for neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Absorption of manganese and iron in a mouse model of hemochromatosis

1 reference

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28 September 2017

Ferroportin and exocytoplasmic ferroxidase activity are required for brain microvascular endothelial cell iron efflux

1 reference

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28 September 2017

1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-κB/RelA acetylation at Lys310

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

A novel N491S mutation in the human SLC11A2 gene impairs protein trafficking and in association with the G212V mutation leads to microcytic anemia and liver iron overload

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Iron disorders of genetic origin: a changing world

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Gender and iron genes may modify associations between brain iron and memory in healthy aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA Let-7d in erythroid cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Mammalian iron transport.

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28 September 2017

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

1 reference

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28 September 2017

Oligodendrocytes and myelination: the role of iron

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28 September 2017

Iron trafficking inside the brain

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28 September 2017

The regulation of cellular iron metabolism

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28 September 2017

Steap proteins: implications for iron and copper metabolism

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28 September 2017

Belgrade rats display liver iron loading

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion

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28 September 2017

A novel R416C mutation in human DMT1 (SLC11A2) displays pleiotropic effects on function and causes microcytic anemia and hepatic iron overload

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Upregulation of iron regulatory proteins and divalent metal transporter-1 isoforms in the rat hippocampus after kainate induced neuronal injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

The rat blood-brain barrier transcriptome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Functional characterization of the E399D DMT1/NRAMP2/SLC11A2 protein produced by an exon 12 mutation in a patient with microcytic anemia and iron overload

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

The Nramp orthologue of Cryptococcus neoformans is a pH-dependent transporter of manganese, iron, cobalt and nickel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Expression and localization of different forms of DMT1 in normal and tumor astroglial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Restricted transport of anti-transferrin receptor antibody (OX26) through the blood-brain barrier in the rat.

1 reference

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28 September 2017

Iron absorption and transport-an update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Identification of the Escherichia coli K-12 Nramp orthologue (MntH) as a selective divalent metal ion transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Transferrin and transferrin receptor function in brain barrier systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Structural organization of the perivascular astrocyte endfeet and their relationship with the endothelial glucose transporter: a confocal microscopy study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Nramp defines a family of membrane proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

pH and the recycling of transferrin during receptor-mediated endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Studies on the mechanism of iron release from transferrin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Iron exchange between transferrin molecules mediated by phosphate compounds and other cell metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 September 2017

Expression of the two mRNA isoforms of the iron transporter Nramp2/DMTI in mice and function of the iron responsive element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

31 May 2018

Cellular distribution of ferric iron, ferritin, transferrin and divalent metal transporter 1 (DMT1) in substantia nigra and basal ganglia of normal and beta2-microglobulin deficient mouse brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

31 May 2018

Identification and characterization of a second mouse Nramp gene.

1 reference

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31 May 2018

Developmental changes in transferrin and iron uptake by the brain in the rat.

1 reference

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31 May 2018

Transferrin and iron uptake by the brain: effects of altered iron status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

31 May 2018

Diminished iron acquisition by cells and tissues of Belgrade laboratory rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

31 May 2018

Iron and transferrin uptake by brain and cerebrospinal fluid in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

31 May 2018

Iron uptake in relation to transferrin degradation in brain and other tissues of rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

31 May 2018

Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation.

1 reference

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21 January 2018

Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload.

1 reference

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21 January 2018

Not all DMT1 mutations lead to iron overload.

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2015.00019

21 January 2018

Cellular distribution of iron in the brain of the Belgrade rat.

1 reference

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21 January 2018

Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat.

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2015.00019

21 January 2018

Identification of functional amino acids in the Nramp family by a combination of evolutionary analysis and biophysical studies of metal and proton cotransport in vivo

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2015.00019

21 January 2018

Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2).

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2015.00019

21 January 2018

Transferrin receptor on endothelium of brain capillaries

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2015.00019

21 January 2018

Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron.

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2015.00019

21 January 2018

Brain capillary endothelial cells mediate iron transport into the brain by segregating iron from transferrin without the involvement of divalent metal transporter 1.

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2015.00019

21 January 2018

Expression of divalent metal transporter 1 in primary hippocampal neurons: reconsidering its role in non-transferrin-bound iron influx.

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2015.00019

21 January 2018

Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1.

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2015.00019

21 January 2018

Characterization and modulation of the transferrin receptor on brain capillary endothelial cells

1 reference

https://api.crossref.org/works/10.3389%2FFNMOL.2015.00019

21 January 2018

The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 November 2018

Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 November 2018

Expression of the neuronal transferrin receptor is age dependent and susceptible to iron deficiency.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 November 2018

Quantification of different transferrin receptor pools in primary cultures of porcine blood-brain barrier endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 November 2018

Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4458610

28 November 2018

The G185R mutation disrupts function of the iron transporter Nramp2

1 reference

https://pubmed.ncbi.nlm.nih.gov/26106291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transferrin receptors on the plasma membrane of cultured rat astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26106291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical perspectives on hereditary hemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26106291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/26106291

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3389/FNMOL.2015.00019

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26106291%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26106291%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26106291%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

ResearchGate publication ID

0 references

Sitelinks

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