(Q27641461)

1

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David H Goetz

2

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Sami Mahrus

3

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Jennifer L Harris

4

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Robert J Fletterick

5

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Charles S Craik

Nature structural biology

6

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language of work or name

English

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publication date

July 2003

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published in

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volume

10

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page(s)

527-34

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issue

7

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cites work

Lymphocyte-mediated cytotoxicity.

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A family of serine esterases in lytic granules of cytolytic T lymphocytes

31 March 2020

1 reference

Granzyme A initiates an alternative pathway for granule-mediated apoptosis.

31 March 2020

1 reference

Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

31 March 2020

1 reference

Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks

31 March 2020

1 reference

Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor

31 March 2020

1 reference

Granzyme A is an interleukin 1 beta-converting enzyme

31 March 2020

1 reference

Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes

31 March 2020

1 reference

Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis

31 March 2020

1 reference

Induction of rapid histone degradation by the cytotoxic T lymphocyte protease Granzyme A.

31 March 2020

1 reference

HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A

31 March 2020

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Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

31 March 2020

1 reference

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

31 March 2020

1 reference

Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes

31 March 2020

1 reference

On the active site of proteases. 3. Mapping the active site of papain; specific peptide inhibitors of papain

31 March 2020

1 reference

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

31 March 2020

1 reference

Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

31 March 2020

1 reference

Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin

31 March 2020

1 reference

Crystal structure of a complement factor D mutant expressing enhanced catalytic activity

31 March 2020

1 reference

Protein structure comparison by alignment of distance matrices

31 March 2020

1 reference

Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence.

31 March 2020

1 reference

A novel serine proteinase (HuTSP) isolated from a cloned human CD8+ cytolytic T cell line is expressed and secreted by activated CD4+ and CD8+ lymphocytes

31 March 2020

1 reference

Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes

31 March 2020

1 reference

Definition and redesign of the extended substrate specificity of granzyme B.

31 March 2020

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The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity

31 March 2020

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Mammalian caspases: structure, activation, substrates, and functions during apoptosis

31 March 2020

1 reference

Human beta-tryptase is a ring-like tetramer with active sites facing a central pore

31 March 2020

1 reference

Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix

31 March 2020

1 reference

The role of ecotin dimerization in protease inhibition

31 March 2020

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Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions

31 March 2020

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Purification and identification of a binding protein for pancreatic secretory trypsin inhibitor: a novel role of the inhibitor as an anti-granzyme A.

31 March 2020

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Crystal structure of the apoptosis-inducing human granzyme A dimer

31 March 2020

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Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase.

31 March 2020

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Calculation of protein extinction coefficients from amino acid sequence data

31 March 2020

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Processing of X-ray diffraction data collected in oscillation mode

31 March 2020

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Automated refinement of protein models

31 March 2020

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Improved methods for building protein models in electron density maps and the location of errors in these models

31 March 2020

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Refinement of macromolecular structures by the maximum-likelihood method

31 March 2020

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ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling

31 March 2020

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Rapid automated molecular replacement by evolutionary search

31 March 2020

1 reference